Effective Treatment of Folliculitis Decalvans With a Combination of Oral Isotretinoin and Rifampicin.

Autor:	Jawade S; Dermatology, Venereology, and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, IND., Singh S; Dermatology, Venereology, and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, IND., Quazi S; Dermatology, Venereology, and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, IND., Dudhe M; Dermatology, Venereology, and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, IND., Neazee S; Dermatology, Venereology, and Leprosy, Datta Meghe Medical College, Datta Meghe Institute of higher education and research, Nagpur, IND., Meghe SR; Dermatology, Venereology, and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND., Jawade S; Musculoskeletal Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 19; Vol. 16 (5), pp. e60633. Date of Electronic Publication: 2024 May 19 (Print Publication: 2024).
DOI:	10.7759/cureus.60633
Abstrakt:	Folliculitis decalvans (FD) is a rare type of inflammatory scalp disorder that leads to scarring alopecia. It is classified as primary neutrophilic cicatricial alopecia. FD presents a challenging scenario in clinical dermatology due to its rarity, resistance to treatment, and potential for scarring alopecia. This inflammatory scalp disorder primarily affects middle-aged adults, predominantly males. While its exact pathogenesis remains uncertain, a deficient host immune response to Staphylococcus aureus infection is hypothesized. Therapeutic interventions for FD pose difficulties, with limited treatment options available A 58-year-old female patient presented with a history of follicular papules that gradually progressed to form clusters of pustules, crusting, and hemorrhagic lesions with tufting of hairs on the crown area of the scalp, and was diagnosed with FD. Considering isotretinoin's role in inhibiting abnormal keratinization and inflammation, and rifampicin's ability to eradicate S. aureus, the combination of both provides a comprehensive approach to tackling the underlying factors contributing to FD. Despite previous unsuccessful treatments, combination therapy with isotretinoin and rifampicin yielded a remarkable outcome, prompting further exploration of this approach. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Jawade et al.)
Databáze:	MEDLINE
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