Should antihypertensives be administrated at bedtime?
| Autor: | Ladebo L; Klinisk Farmakologi, Farmaci og Miljømedicin, Institut for Folkesundhed, Syddansk Universitet., Thomassen ER; Klinisk Farmakologi, Farmaci og Miljømedicin, Institut for Folkesundhed, Syddansk Universitet., Bryne M; Klinisk Farmakologi, Farmaci og Miljømedicin, Institut for Folkesundhed, Syddansk Universitet., Zwisler ADO; Kardiologisk Afdeling, Odense Universitetshospital.; REHPA, Dansk Videncenter for Rehabilitering og Palliativ Sygepleje, Odense Universitetshospital, Nyborg.; Institut for Klinisk Forskning, Syddansk Universitet., Christensen B; Forskningsenheden for Almen Medicin, Institut for Folkesundhed, Aarhus Universitet.; Forskningsenheden for Almen Praksis, Aarhus Universitet., Olsen MH; Blodprøver og Biokemi, Institut for Klinisk Medicin, Aarhus Universitetshospital., Hallas J; Intern Medicinsk Afdeling, Københavns Universitetshospital - Holbæk Sygehus.; Institut for Regional Sundhedsforskning, Syddansk Universitet. |
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| Jazyk: | dánština |
| Zdroj: | Ugeskrift for laeger [Ugeskr Laeger] 2024 Jun 10; Vol. 186 (24). Date of Electronic Publication: 2024 Jun 10. |
| DOI: | 10.61409/V11230700 |
| Abstrakt: | Ongoing monitoring and targeted treatment are important to ensure the best blood-pressure control and thus prevent cardiovascular risks. In this review, we evaluate the findings of four clinical studies investigating the effects of morning versus bedtime dosing of antihypertensives. In three out of four studies, overwhelming results were found favouring bedtime dosing. The same studies have been criticized for mechanistic implausible results and multiple study biases. No harmful effects were reported in relation to bedtime dosing. Thus, antihypertensives can be taken as it is most convenient for the patient. (Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.) |
| Databáze: | MEDLINE |
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