Tubulointerstitial nephritis with storiform fibrosis in a patient with angioimmunoblastic T-cell lymphoma.

Autor: Fukuda H; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Department of Nephrology, Nagasaki Harbor Medical Center, Nagasaki, Japan., Kitamura M; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. mineaki82@yahoo.co.jp.; Department of Nephrology, Nagasaki Harbor Medical Center, Nagasaki, Japan. mineaki82@yahoo.co.jp., Sawase A; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Department of Nephrology, Nagasaki Harbor Medical Center, Nagasaki, Japan., Uramatsu T; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Department of Nephrology, Nijigaoka Hospital, Nagasaki, Japan., Yamashita H; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.; Department of Nephrology, Nagasaki Harbor Medical Center, Nagasaki, Japan., Tsushima H; Department of Hematology, Nagasaki Harbor Medical Center, Nagasaki, Japan., Irie J; Department of Pathology, Nagasaki Harbor Medical Center, Nagasaki, Japan., Katafuchi E; Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Kato S; Division of Pathology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan., Takeuchi M; Department of Pathology, Kurume University, Kurume, Japan., Ohshima K; Department of Pathology, Kurume University, Kurume, Japan., Nakayama T; Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Mukae H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Nishino T; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Jazyk: angličtina
Zdroj: CEN case reports [CEN Case Rep] 2024 Jun 20. Date of Electronic Publication: 2024 Jun 20.
DOI: 10.1007/s13730-024-00901-2
Abstrakt: We present a case of an angioimmunoblastic T-cell lymphoma (AITL) and tubulointerstitial nephritis with storiform fibrosis in a 76-year-old man. The patient exhibited lymphadenopathy, polyclonal hypergammaglobulinemia, and renal dysfunction and was diagnosed with AITL on the basis of lymph node biopsy findings. The serum IgG4 level was highly elevated. Renal biopsy revealed IgG4-positive plasma cells and storiform fibrosis without infiltration of AITL, and the findings indicated IgG4-related kidney disease (IgG4-RKD). Following THPCOP therapy for AITL, the renal function improved. While diagnosing IgG4-RKD in a patient with AITL poses challenges, follicular helper T cell involvement appeared crucial in AITL and renal tubulointerstitial lesions in this case.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.)
Databáze: MEDLINE
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