Racial disparity in prostate cancer: an outlook in genetic and molecular landscape.

Autor: Kaushal JB; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA., Raut P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA., Muniyan S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA., Siddiqui JA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE-68198, USA., Alsafwani ZW; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA., Seshacharyulu P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE-68198, USA., Nair SS; Department of Urology and the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Tewari AK; Department of Urology and the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA. sbatra@unmc.edu.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE-68198, USA. sbatra@unmc.edu.; Division of Urology, Department of Surgery, University of Nebraska Medical Center, Omaha, NE-68198, USA. sbatra@unmc.edu.; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE-68198, USA. sbatra@unmc.edu.
Jazyk: angličtina
Zdroj: Cancer metastasis reviews [Cancer Metastasis Rev] 2024 Dec; Vol. 43 (4), pp. 1233-1255. Date of Electronic Publication: 2024 Jun 20.
DOI: 10.1007/s10555-024-10193-8
Abstrakt: Prostate cancer (PCa) incidence, morbidity, and mortality rates are significantly impacted by racial disparities. Despite innovative therapeutic approaches and advancements in prevention, men of African American (AA) ancestry are at a higher risk of developing PCa and have a more aggressive and metastatic form of the disease at the time of initial PCa diagnosis than other races. Research on PCa has underlined the biological and molecular basis of racial disparity and emphasized the genetic aspect as the fundamental component of racial inequality. Furthermore, the lower enrollment rate, limited access to national-level cancer facilities, and deferred treatment of AA men and other minorities are hurdles in improving the outcomes of PCa patients. This review provides the most up-to-date information on various biological and molecular contributing factors, such as the single nucleotide polymorphisms (SNPs), mutational spectrum, altered chromosomal loci, differential gene expression, transcriptome analysis, epigenetic factors, tumor microenvironment (TME), and immune modulation of PCa racial disparities. This review also highlights future research avenues to explore the underlying biological factors contributing to PCa disparities, particularly in men of African ancestry.
Competing Interests: Declarations Ethics approval and consent to participate Not applicable. Conflict of interest Dr. Surinder Batra is one of the co-founders of Sanguine Diagnostics and Therapeutics, Inc. Dr. Ash Tewari has served as site-PI on sponsored clinical trials from Kite Pharma Inc., Lumicell, Inc., Dendron Pharmaceuticals, LLC, Oncovir Inc., Blue Earth Diagnostics Ltd., RhoVac ApS., Bayer HealthCare Pharmaceuticals Inc., Janssen Research and Development, LLC. Dr. Tewari has served as an unpaid consultant to Roivant Biosciences and as an advisor to Promaxo. He owns equity in Promaxo. The other authors disclosed no potential conflicts of interest.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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