Factor XIII in major burns coagulation.

Autor: Guilabert P; Anesthesia and Critical Care Department. University Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain. Electronic address: patricia.guilabert@gmail.com., Abarca L; Anesthesia and Critical Care Department. University Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain. Electronic address: labarcavilchez@gmail.com., Usúa G; Anesthesia and Critical Care Department. University Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain. Electronic address: gemmausua@gmail.com., Martin N; Anesthesia and Critical Care Department. Hospital Clinic Barcelona, Spain. Electronic address: nmartinmarata@gmail.com., Alonso M; Anesthesia and Critical Care Department. University Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain. Electronic address: mrlns.07@gmail.com., Barret JP; Plastic Surgery Department and Burn Centre. University Hospital Vall d'Hebron. Autonomous University of Barcelona, Barcelona, Spain. Electronic address: jpbarret@vhebron.net., Colomina MJ; Anesthesia and Critical Care Department, University Bellvitge Hospital, University of Barcelona, Barcelona, Spain. Electronic address: mjcolomina@bellvitgehospital.cat.
Jazyk: angličtina
Zdroj: Burns : journal of the International Society for Burn Injuries [Burns] 2024 Sep; Vol. 50 (7), pp. 1769-1778. Date of Electronic Publication: 2024 May 10.
DOI: 10.1016/j.burns.2024.05.002
Abstrakt: Background: In the days following a burn injury, major burn patients (MBP) present a multifactorial coagulation disorder known as acute burn-induced coagulopathy. Several studies have investigated coagulation in MBPs; however, Factor XIII (FXIII), which converts fibrin monomers into a stable clot and promotes wound healing, has not yet been studied.
Objective: To determine the kinetics of FXIII and other coagulation factors and cofactors in MBPs in order to clarify coagulopathy in these patients and its potential relationship with surgical bleeding.
Methods: Prospective observational pilot study of the kinetics of FXIII and other coagulation factors and cofactors in MBPs during the first 30 days of burn injury.
Results: FXIII levels show a significant decline of 75.10% in the interval between the burn injury and surgery, and a decline of 87.70% in the 24 h following surgery. Patients undergo surgery with a median antigenic FXIII of 32%. Plasma levels of most factors decrease significantly 24 h after the burn injury.
Conclusion: MBPs experience a significant decrease in plasma levels of FXIII from the time of admission up to 24 h after surgery. Abnormally low levels were observed at the time of surgery that could not be detected by other coagulation tests. The decrease in most factors at 24 h seems to be associated with dilution due to intensive fluid resuscitation.
Competing Interests: Declaration of Competing Interest The authors declare not having any conflict of interest related to this manuscript.
(Copyright © 2024 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.)
Databáze: MEDLINE
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