Impact of resistant starch: Absorption of dietary minerals, glycemic index and oxidative stress in healthy rats.

Autor: Nisa MU; Department of Nutritional Sciences, Faculty of Medical Sciences, Government College University, 38000 Faisalabad, Pakistan. Electronic address: linknisa@gcuf.edu.pk., Kasankala LM; Department of Food Science and Nutrition, Tanzania Food and Nutrition Centre, Tanzania. Electronic address: ladislaus.kasankala@tfnc.go.tz., Khan FA; University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, 40100 Sargodha, Pakistan. Electronic address: faima.atta@dnsc.uol.edu.pk., Al-Asmari F; Department of Food and Nutrition Sciences, College of Agricultural and Food Sciences, King Faisal University, 31982 Al-Ahsa, Saudi Arabia. Electronic address: falasmari@kfu.edu.sa., Rahim MA; Department of Food Science & Nutrition, Faculty of Medicine and Allied Health Sciences, Times Institute Multan, 60700 Pakistan. Electronic address: mabdulrahim@t.edu.pk., Hussain I; Department of Food Science and Technology, Faculty of Agriculture, University of Poonch, Rawalakot, Azad Kashmir, Pakistan. Electronic address: imtiazupr@yahoo.com., Angelov A; Department of Biotechnology, University of Food Technologies, 26 Maritza Blvd., 4000 Plovdiv, Bulgaria. Electronic address: angelov@uft-bio.com., Bartkiene E; Department of Food Safety and Quality, Faculty of Veterinary, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania; Faculty of Animal Sciences, Institute of Animal Rearing Technologies, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania. Electronic address: elena.bartkiene@lsmu.lt., Rocha JM; Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal; LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal; ALiCE-Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal. Electronic address: jmfrocha@fc.up.pt.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2024 Aug; Vol. 62, pp. 1-9. Date of Electronic Publication: 2024 May 10.
DOI: 10.1016/j.clnesp.2024.04.021
Abstrakt: Background & Aims: Resistant starch (RS) is a prebiotic fiber that has been scientifically shown to control the development of obesity. Prebiotic role of RS has also seen to be very important as it helps gut bacteria to regulate fermentation and fatty acid production. This study aimed to check the different levels of RS on glycemic index, oxidative stress and mineral absorption rate in healthy rat models. To evaluate these objectives, the trial was conducted for 40 days of follow up; 10 days were the adjustment period and the collection period over 30 days.
Methods: Thirty-six healthy female Wistar rats were divided into 4 groups of (9 animals each) NC (Normal Control: without resistant starch), RS 0.20 (resistant starch: 0.20 g/kg body weight), RS 0.30 (resistant starch: 0.30 g/kg body weight), RS 0.40 (resistant starch: 0.40 g/kg body weight). All the diets were isocaloric and isonitroginous.
Results: The impact of different levels of RS on the dry-matter intake (DMI) presented statistically significant results (p ≤ 0.05): DMI was reduced in RS (0.02) fed rats as compared to NC rats in first 3 weeks; and after 4th and 5th weeks, there was a DMI reduction of 28% in RS (0.04) fed rats. Moreover, there was no significant increase in the nutrient intake in all RS diets. The dry-matter (DM) digestibility was statistically significantly (P ≤ 0·05), which increased in all rats fed with different level of RS. The weight loss showed statistically significant results: RS (0.04) exhibited 19 g reduction in weight as compared with NC rats. Significant increase was observed in total oxidant status (TOS), in all the RS fed rats when compared with NC rats. The levels of Mg, Ca, Fe and Zn were shown to be decrease in feces analysis, which proves their better absorbance in gut. Statistically significant increase was observed in antioxidant capacity, whereas significant decrease was observed in the total weight of the animals, showing the role of RS in controlling obesity.
Conclusions: Overall, significant results were found in all dosage level of RS but long term administration of the higher dosage level (RS 0.40 ) may need to be studied for enhanced results. RS can help improve insulin sensitivity in overweight adults.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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