Talaesthanes A-C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21.
| Autor: | Chen JQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Li S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Clinical Trial Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China., Fan RZ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Sun ZH; Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, China., Zhu XY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Yin AP; Department of Clinical Laboratory, The Third People's Hospital of Dongguan, Dongguan 523326, China., Tang GH; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: tanggh5@mail.sysu.edu.cn., Yin S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. |
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| Jazyk: | angličtina |
| Zdroj: | Fitoterapia [Fitoterapia] 2024 Sep; Vol. 177, pp. 106085. Date of Electronic Publication: 2024 Jun 18. |
| DOI: | 10.1016/j.fitote.2024.106085 |
| Abstrakt: | Three new meroterpenoids (1-3) and ten known ones (4-13) were obtained from the endophytic fungus Talaromyces primulinus H21 isolated from the plant of Euphorbia sikkimensis. Their structures including their absolute configurations were elucidated by extensive analysis of spectroscopic data such as HR-ESI-MS, 1D/2D NMR, and X-ray diffraction of single crystal together with comparison of experimental ECD with calculated ECD. All compounds were examined for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells, and compounds 3, 9, 12, and 13 exhibited certain inhibition on NO production, with IC Competing Interests: Declaration of competing interest The authors declare that there are no competing interests associated with this work. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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