A singlet oxygen-storing covalent organic framework for "Afterglow" photodynamic therapy.

Autor: Wang J; Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570216, China., Bai L; Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China., Huang T; Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570216, China., Wang Y; Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570216, China., Cheng Z; Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China., Liu Q; Department of Urology, Tianjin First Central Hospital, Tianjin 300192, China., Su X; Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570216, China. Electronic address: sxf@hainanu.edu.cn., Zhao L; Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China. Electronic address: zhaolinlu@hainmc.edu.cn., Lu F; Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570216, China. Electronic address: lufei@hainanu.edu.cn.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2024 Nov; Vol. 673, pp. 679-689. Date of Electronic Publication: 2024 Jun 17.
DOI: 10.1016/j.jcis.2024.06.124
Abstrakt: Photodynamic therapy (PDT) is an emerging treatment but often restricted by the availability of oxygen. Enhancing the lifespan of singlet oxygen ( 1 O 2 ) by fractionated generation is an effective approach to improve the efficacy of PDT. Herein, an imine-based nanoscale COF (TpDa-COF) has been synthesized and functionalized with a pyridone-derived structure (Py) to create a 1 O 2 -storing nanoplatform TpDa-COF@Py, which can reversibly capture and release 1 O 2 . Under 660 nm laser exposure, Py interacts with 1 O 2 produced by the porphyrin motif in COF backbones to generate 1 O 2 -enriched COF (TpDa-COF@Py + hv), followed by the release of 1 O 2 through retro-Diels-Alder reactions at physiological temperatures. The continuous producing and releasing of 1 O 2 upon laser exposure leads to an "afterglow" effect and a prolonged 1 O 2 lifespan. In vitro cytotoxicity assays demonstrates that TpDa-COF@Py + hv exhibits an extremely low half-maximal inhibitory concentration (IC 50 ) of 0.54 µg/mL on 4T1 cells. Remarkably, the Py-mediated TpDa-COF@Py nanoplatform demonstrates enhanced cell-killing capability under laser exposure, attributed to the sustained 1 O 2 cycling, compared to TpDa-COF alone. Further in vivo assessment highlights the potential of TpDa-COF@Py + hv as a promising strategy to enhance phototheronostics and achieve effective tumor regression. Accordingly, the study supplies a generalized 1 O 2 "afterglow" nanoplatform to improve the effectiveness of PDT.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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