A fast thermal desorption unit for micro thermal desorption tubes, Part I: Development of the system and proof of concept measurements with hyper-fast gas chromatography.

Autor: Chopra MD; Institute of Nutritional and Food Sciences, University of Bonn, Friedrich-Hirzebruch Allee 5, D-53115 Bonn, Germany. Electronic address: miriam.chopra@uni-bonn.de., Menger FA; Institute of Nutritional and Food Sciences, University of Bonn, Friedrich-Hirzebruch Allee 5, D-53115 Bonn, Germany; Chemisches und Veterinäruntersuchungsamt Ostwestfalen-Lippe (CVUA-OWL), Westerfeldstraße 1, D-32758 Detmold, Germany., Duong B; Institute of Nutritional and Food Sciences, University of Bonn, Friedrich-Hirzebruch Allee 5, D-53115 Bonn, Germany; HyperChrom Deutschland GmbH, Konrad-Zuse-Strasse 3, 53347 Alfter, Germany., Wüst M; Institute of Nutritional and Food Sciences, University of Bonn, Friedrich-Hirzebruch Allee 5, D-53115 Bonn, Germany., Boeker P; Institute of Nutritional and Food Sciences, University of Bonn, Friedrich-Hirzebruch Allee 5, D-53115 Bonn, Germany; HyperChrom Deutschland GmbH, Konrad-Zuse-Strasse 3, 53347 Alfter, Germany. Electronic address: boeker@uni-bonn.de.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2024 Aug 16; Vol. 1730, pp. 465039. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1016/j.chroma.2024.465039
Abstrakt: A system consisting of a thermal desorption unit (TDU) and micro thermal desorption tubes (μTD-tubes, 1.4 mm I.D., 10mg Tenax TA) for fast desorption of analytes was developed for the efficient combination of hyper fast gas chromatography with thermal desorption. The fast desorption is achieved by a significantly reduced thermal mass compared to conventional thermal desorption tubes. Therefore, extremely fast heating and cooling cycles are possible. Proof of concept measurements combining the new setup with a flow-field thermal gradient gas chromatograph (FF-TG-GC) and FID detection show good precision and linearity with R 2 ≥0.995 in the analysis of an n-alkane mix (C 8 -C 20 ). Thermal desorption occurs within 12s. The impact of reduced μTD-tube dimensions on desorption time, full width at half maximum (FWHM), breakthrough volumes, tube flow rates ergo linear velocities, porosity and back pressure is discussed.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Miriam Chopra reports financial support was provided by Federal Ministry of Defence Bonn. Peter Boeker reports a relationship with HyperChrom Deutschland GmbH that includes: board membership, employment, and equity or stocks. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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