Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants.

Autor: Meister TL; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Institute for Infection Research and Vaccine Development (IIRVD), Centre for Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Frericks N; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Kleinert RDV; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Rodríguez E; German Centre for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Steinmann J; Institute of Clinical Hygiene, Medical Microbiology and Infectiology, General Hospital Nürnberg, Paracelsus Medical University, Nuremberg, Germany.; Institute of Medical Microbiology, University Hospital of Essen, Essen, Germany., Todt D; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; European Virus Bioinformatics Center (EVBC), Jena, Germany., Brown RJP; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany., Steinmann E; Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.; German Centre for Infection Research (DZIF), External Partner Site, Bochum, Germany.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Jun 20; Vol. 18 (6), pp. e0012264. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0012264
Abstrakt: Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Meister et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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