Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol.

Autor: Das JK; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.; Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan., Padhani ZA; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan., Khan M; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan., Mirani M; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan., Rizvi A; Centre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan., Chauhadry IA; Centre of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan., Yasin R; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan., Ismail T; Institute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan., Akhtar S; Institute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan., Begum K; Nutrition Research Laboratory, The Aga Khan University, Karachi, Pakistan., Iqbal J; Nutrition Research Laboratory, The Aga Khan University, Karachi, Pakistan., Humayun K; Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan., Naseem HA; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan., Malik KA; School of Life Sciences, Forman Christian College (A Chartered University), Lahore, Pakistan.; Pakistan Academy of Sciences, Islamabad, Pakistan., Bhutta ZA; Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.; Center for Global Child Health, Hospital for Sick Children, Toronto, Canada.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jun 20; Vol. 19 (6), pp. e0304462. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0304462
Abstrakt: Background: Zinc deficiency poses significant health risks, particularly in low-income settings. This study aims to evaluate the impact of agronomically zinc biofortified (fermented and non-fermented) and post-harvest wheat flour flatbread on zinc status and metabolic health in adolescents and adult women in rural Pakistan.
Methods: A four-arm triple-blind randomized controlled trial will be conducted in a rural district of Pakistan. Participants (adolescents aged 10-19 and adult women aged 20-40) will be assigned to receive fermented or unfermented high zinc agronomically biofortified wheat flour flatbread, post-harvest zinc-fortified wheat flour flatbread, or low zinc conventional whole wheat flour flatbread. The meal would be served once a day, six days a week for six months. The study aims to enroll 1000 participants and will be analyzed based on the intention-to-treat principle. The trial is registered with number NCT06092515.
Outcomes: Primary outcomes will include serum zinc concentration and metabolic markers, while secondary outcomes include anthropometric measurements, blood pressure, and dietary intake.
Conclusion: This trial will provide valuable insights into the efficacy of agronomically zinc biofortified wheat flour in improving zinc status and metabolic health. Findings may inform public health strategies to combat zinc deficiency in resource-limited settings.
Competing Interests: The authors have declared that no competing interests.
(Copyright: © 2024 Das et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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