Timely Albumin Infusion May Improve Resource Utilization in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis.

Autor: Kim WR; Division of Gastroenterology and Hepatology Stanford University, Stanford, CA, USA., Raghunathan K; Department of Anesthesiology Duke University, Durham, NC, USA., Martin GS; Department of Medicine Emory University, Atlanta, GA, USA., Davis EA; Grifols SSNA, Research Triangle Park, NC, USA., Sindhwani NS; Grifols SSNA, Research Triangle Park, NC, USA., Telang S; Boston Strategic Partners Inc., Boston, MA, USA., Lodaya K; Boston Strategic Partners Inc., Boston, MA, USA.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2024 Jun 08; Vol. 2024, pp. 6673823. Date of Electronic Publication: 2024 Jun 08 (Print Publication: 2024).
DOI: 10.1155/2024/6673823
Abstrakt: Spontaneous bacterial peritonitis is a life-threatening complication of cirrhosis that can increase healthcare utilization. The impact of albumin administration timing on hospital resource utilization and its optimal timing is unclear, despite its efficacy in improving survival for cirrhosis patients with spontaneous bacterial peritonitis. A retrospective study was conducted to evaluate the influence of the timing of albumin administration on the length of stay and total hospital cost for patients with cirrhosis and spontaneous bacterial peritonitis who require fluid resuscitation. The study utilized de-identified data from Cerner Health Facts® data. Adult inpatients with a diagnosis of cirrhosis and SBP receiving ≥1 antibiotic and fluid resuscitation between January 1, 2009, and April 30, 2018, were included and stratified by albumin administration timing: ≤24 hours from hospital admission ("timely albumin") or >24 hours of admission or no albumin ("non-timely albumin"). We used a Kaplan-Meier curve with log-rank test to evaluate the association between timing of albumin administration and time to hospital discharge and a generalized linear model to examine the association between albumin timing and total hospital costs. We identified 1,308 hospitalizations, of which 301 contained valid cost data. The timely albumin group had a median time to discharge of 6.95 days compared to 7.78 days in the non-timely group ( p = 0.02). Cost model showed that receiving timely albumin incurred 16% lower costs ( p = 0.027) than patients in the non-timely albumin group. Timely albumin administration with an antibiotic regimen may shorten the length of stay and lower costs, thereby reducing hospital resource utilization in patients with cirrhosis and spontaneous bacterial peritonitis requiring fluid resuscitation.
Competing Interests: Dr. Navreet Sindhwani and Dr. E. Anne Davis were employees of Grifols SSNA at the time of this study. Santosh Telang was an employee of Boston Strategic Partners, Inc. at the time of this study. Dr. Karthik Raghunathan is a paid consultant for Grifols SSNA. Further information is available at https://openpaymentsdata.cms.gov/physician/803766. Dr. Kim is a paid consultant for Grifols SSNA. Dr. Greg Martin and Dr. Kunal Lodaya have no conflicts of interest to declare.
(Copyright © 2024 W. Ray Kim et al.)
Databáze: MEDLINE
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