General In Situ Engineering of Carbon-Based Materials on Carbon Fiber for In Vivo Neurochemical Sensing.

Autor: Zeng H; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Ren G; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Gao N; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Xu T; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Jin P; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Yin Y; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Liu R; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Zhang S; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Zhang M; School of Chemistry and Life Resources, Renmin University of China, Beijing, 100872, P.R. China., Mao L; College of Chemistry, Beijing Normal University, Beijing, 100875, China.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 02; Vol. 63 (36), pp. e202407063. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1002/anie.202407063
Abstrakt: Developing real-time, dynamic, and in situ analytical methods with high spatial and temporal resolutions is crucial for exploring biochemical processes in the brain. Although in vivo electrochemical methods based on carbon fiber (CF) microelectrodes are effective in monitoring neurochemical dynamics during physiological and pathological processes, complex post modification hinders large-scale productions and widespread neuroscience applications. Herein, we develop a general strategy for the in situ engineering of carbon-based materials to mass-produce functional CFs by introducing polydopamine to anchor zeolitic imidazolate frameworks as precursors, followed by one-step pyrolysis. This strategy demonstrates exceptional universality and design flexibility, overcoming complex post-modification procedures and avoiding the delamination of the modification layer. This simplifies the fabrication and integration of functional CF-based microelectrodes. Moreover, we design highly stable and selective H + , O 2 , and ascorbate microsensors and monitor the influence of CO 2 exposure on the O 2 content of the cerebral tissue during physiological and ischemia-reperfusion pathological processes.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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