Unusual Cutibacterium acnes splenic abscess with bacteremia in an immunocompetent man: phylotyping and clonal complex analysis.

Autor: Roudeau A; Department of Internal Medicine and Infectious Diseases, Groupe Hospitalier Diaconesses- Croix Saint-Simon, 125, rue d'Avron, Paris, 75020, France., Corvec S; Service de Bactériologie et des Contrôles Microbiologiques, CHU Nantes, Université de Nantes, INSERM, INCIT U1302, Nantes, France., Heym B; Laboratoire des Centres de Santé et Hôpitaux d'Île-de-France, Groupe Hospitalier Diaconesses- Croix Saint-Simon, 125, rue d'Avron, Paris, France., d'Epenoux LR; Service de Bactériologie et des Contrôles Microbiologiques, CHU Nantes, Université de Nantes, INSERM, INCIT U1302, Nantes, France., Lidove O; Department of Internal Medicine and Infectious Diseases, Groupe Hospitalier Diaconesses- Croix Saint-Simon, 125, rue d'Avron, Paris, 75020, France., Zeller V; Department of Internal Medicine and Infectious Diseases, Groupe Hospitalier Diaconesses- Croix Saint-Simon, 125, rue d'Avron, Paris, 75020, France. vzeller@hopital-dcss.org.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2024 Jun 19; Vol. 24 (1), pp. 601. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1186/s12879-024-09467-x
Abstrakt: Background: Cutibacterium acnes is an anaerobic bacterium mostly implicated in cutaneous and body-implant infections. Splenic abscess is a rare entity and C. acnes abscesses have only exceptionally been reported. We describe a spontaneous splenic C. acnes abscess in an immunocompetent man with no predisposing factors or identified portal of entry. His isolates were subjected to single-locus sequence typing (SLST) to explore their genetic relatedness and better understand this rare infection.
Case Presentation: A splenic abscess was diagnosed on a computed-tomography scan in a 74-year-old man with chronic abdominal pain. No risk factor was identified. Abscess-drained pus and post-drainage blood cultures grew C. acnes. SLST of abscess and blood isolates showed that they belonged to the same C. acnes SLST type C1 found in normal skin and rarely in inflammatory skin disease. Specific virulence factors could not be identified.
Conclusion: C. acnes abscesses are extremely rare and can develop in immunocompetent patients without an identifiable portal of entry. Molecular typing of clinical isolates can help confirm infection (versus contamination) and enables genetic background comparisons. Further research is needed to understand C. acnes tropism and virulence.
(© 2024. The Author(s).)
Databáze: MEDLINE
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