Variable effect of the post-partum menstrual cycle on aldosterone and renin in women with recent preeclampsia.

Autor: Veldhuizen GP; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands.; Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany., Alnazer RM; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Kroon AA; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Spaanderman MEA; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands.; Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands., de Leeuw PW; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands. p.deleeuw@maastrichtuniversity.nl.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands. p.deleeuw@maastrichtuniversity.nl.
Jazyk: angličtina
Zdroj: Journal of human hypertension [J Hum Hypertens] 2024 Sep; Vol. 38 (9), pp. 649-654. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1038/s41371-024-00926-1
Abstrakt: The purpose of the present study is to identify the impact of the postpartum menstrual cycle on aldosterone, renin, and their ratio of women with and without a preeclamptic pregnancy in the past. To this end, we analysed the data from 59 women with a history of preeclampsia and 39 healthy parous controls. Five to seven months post-partum, we measured aldosterone, renin, and the aldosterone-to-renin ratio during both the follicular and the luteal phase of the menstrual cycle. All measurements were taken in the supine position in the morning. Patients had maintained a standardized sodium diet in the week prior to the measurements. Our results show that in both post-partum women with recent preeclampsia and controls, average levels of renin and aldosterone are significantly elevated in the luteal phase as compared to the follicular phase. The aldosterone-to-renin ratio does not differ between the two phases in either group. Compared to controls, women with recent preeclampsia have significantly lower levels of renin, aldosterone, and aldosterone-to-renin ratio in the follicular phase. This remained consistent in the luteal phase, except for renin. A close correlation existed between the luteal and follicular aldosterone-to-renin ratio in the control group but not in the preeclampsia group. We conclude that both renin and aldosterone are significantly affected by the menstrual cycle whereas the resulting aldosterone-to-renin ratio is not. Post-partum women with recent preeclampsia tend to have lower values for aldosterone and the aldosterone-to-renin ratio than controls.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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