Nutrition and the gut-brain axis in neonatal brain injury and development.

Autor: Perez KM; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America., Strobel KM; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America., Hendrixson DT; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America., Brandon O; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America., Hair AB; Division of Neonatology, Baylor College of Medicine, Houston, TX, United States of America., Workneh R; St Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia., Abayneh M; St Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia., Nangia S; Department of Neonatology, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India., Hoban R; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America., Kolnik S; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America., Rent S; Division of Neonatology, Duke University, Durham, NC, United States of America., Salas A; Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, United States of America., Ojha S; School of Medicine, University of Nottingham, Nottingham, United Kingdom., Valentine GC; Division of Neonatology, University of Washington/Seattle Children's Hospital, Seattle, WA, United States of America; Department of Oral Health Sciences, University of Washington, Seattle, WA, United States of America; Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, TX, United States of America. Electronic address: gcvalent@uw.edu.
Jazyk: angličtina
Zdroj: Seminars in perinatology [Semin Perinatol] 2024 Aug; Vol. 48 (5), pp. 151927. Date of Electronic Publication: 2024 Jun 13.
DOI: 10.1016/j.semperi.2024.151927
Abstrakt: Early nutritional exposures, including during embryogenesis and the immediate postnatal period, affect offspring outcomes in both the short- and long-term. Alterations of these modifiable exposures shape the developing gut microbiome, intestinal development, and even neurodevelopmental outcomes. A gut-brain axis exists, and it is intricately connected to early life feeding and nutritional exposures. Here, we seek to discuss the (1) origins of the gut-brain access and relationship with neurodevelopment, (2) components of human milk (HM) beyond nutrition and their role in the developing newborn, and (3) clinical application of nutritional practices, including fluid management and feeding on the development of the gut-brain axis, and long-term neurodevelopmental outcomes. We conclude with a discussion on future directions and unanswered questions that are critical to provide further understanding and insight into how clinicians and healthcare providers can optimize early nutritional practices to ensure children not only survive, but thrive, free of neurodevelopmental impairment.
Competing Interests: Declaration of competing interest The authors report no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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