Association between bronchopulmonary dysplasia severity and its risk factors and long-term outcomes in three definitions: a historical cohort study.

Autor:	Katz TA; Neonatology, Emma Children's Hospital UMC, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands., van Kaam AH; Amsterdam Reproduction and Development, Amsterdam, The Netherlands.; Amsterdam University Medical Centers, Amsterdam, The Netherlands., Zuithoff NPA; University Medical Center Utrecht, Utrecht, The Netherlands., Mugie SM; Department of Pediatrics, Tergooi Medical Center, Hilversum, The Netherlands.; Emma Children's Hospital UMC, Amsterdam, The Netherlands., Beuger S; Department of Pediatrics and Neonatology, North West Hospital Group, Alkmaar, The Netherlands., Blok GJ; Department of Pediatrics and Neonatology, North West Hospital Group, Alkmaar, The Netherlands., van Kempen AAMW; Department of Pediatrics and Neonatology, OLVG, Amsterdam, The Netherlands., van Laerhoven H; Department of Pediatrics, OLVG, Amsterdam, The Netherlands., Lutterman CAM; Department of Pediatrics, Flevoziekenhuis, Almere, The Netherlands., Rijpert M; Department of Pediatrics, Zaans Medical Center, Zaandam, The Netherlands., Schiering IA; Department of Pediatrics, Spaarne Hospital Haarlem, Haarlem, The Netherlands., Ran NC; Department of Pediatrics, Red Cross Hospital, Beverwijk, The Netherlands., Visser F; Department of Pediatrics, Amstelland Hospital, Amstelveen, The Netherlands., van Straaten E; Department of Pediatrics, Bovenij Hospital, Amsterdam, The Netherlands., Aarnoudse-Moens CSH; Psychosocial Department, Emma Children's Hospital UMC, Amsterdam, The Netherlands., van Wassenaer-Leemhuis AG; Neonatology, Emma Children's Hospital UMC, Amsterdam, The Netherlands.; Department of Neonatology, Emma Children's Hospital UMC, Amsterdam, The Netherlands., Onland W; Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands w.onland@amsterdamumc.nl.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2024 Dec 20; Vol. 110 (1), pp. 51-56. Date of Electronic Publication: 2024 Dec 20.
DOI:	10.1136/archdischild-2024-326931
Abstrakt:	Objective: To compare the association of the severity categories of the 2001-National Institutes of Health (NIH), the 2018-NIH and the 2019-Jensen bronchopulmonary dysplasia (BPD) definitions with neurodevelopmental and respiratory outcomes at 2 and 5 years' corrected age (CA), and several BPD risk factors. Design: Single-centre historical cohort study with retrospective data collection. Setting: Infants born between 2009 and 2015 at the Amsterdam University Medical Centers, location Amsterdam Medical Center. Patients: Preterm infants born at gestational age (GA) <30 weeks and surviving up to 36 weeks' postmenstrual age. Interventions: Perinatal characteristics, (social) demographics and comorbidities were collected from the electronic patient records. Main Outcome Measures: The primary outcomes were neurodevelopmental impairment (NDI) or late death, and respiratory morbidity at 2 and 5 years' CA. Using logistic regression and Brier scores, we investigated if the ordinal grade severity is associated with incremental increase of adverse long-term outcomes. Results: 584 preterm infants (median GA: 28.1 weeks) were included and classified according to the three BPD definitions. None of the definitions showed a clear ordinal incremental increase of risk for any of the outcomes with increasing severity classification. No significant differences were found between the three BPD definitions (Brier scores 0.169-0.230). Respiratory interventions, but not GA, birth weight or small for GA, showed an ordinal relationship with BPD severity in all three BPD definitions. Conclusion: The severity classification of three BPD definitions showed low accuracy of the probability forecast on NDI or late death and respiratory morbidity at 2 and 5 years' CA, with no differences between the definitions. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.)
Databáze:	MEDLINE
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