The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program.

Autor:	Burton OT; Department of Pathology, University of Cambridge, Cambridge, UK; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium; Babraham Institute, Babraham Research Campus, Cambridge, UK., Bricard O; Babraham Institute, Babraham Research Campus, Cambridge, UK., Tareen S; Babraham Institute, Babraham Research Campus, Cambridge, UK., Gergelits V; Department of Pathology, University of Cambridge, Cambridge, UK; Babraham Institute, Babraham Research Campus, Cambridge, UK., Andrews S; Babraham Institute, Babraham Research Campus, Cambridge, UK., Biggins L; Babraham Institute, Babraham Research Campus, Cambridge, UK., Roca CP; Babraham Institute, Babraham Research Campus, Cambridge, UK., Whyte C; Babraham Institute, Babraham Research Campus, Cambridge, UK., Junius S; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium., Brajic A; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium., Pasciuto E; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium; University of Antwerp, Center of Molecular Neurology, Antwerp, Belgium., Ali M; Department of Pathology, University of Cambridge, Cambridge, UK., Lemaitre P; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium., Schlenner SM; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium., Ishigame H; Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Near-InfraRed Photo-Immunotherapy Research Institute, Kansai Medical University, Hirakata, Osaka 573-1010, Japan., Brown BD; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dooley J; Department of Pathology, University of Cambridge, Cambridge, UK; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium; Babraham Institute, Babraham Research Campus, Cambridge, UK., Liston A; Department of Pathology, University of Cambridge, Cambridge, UK; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium; Babraham Institute, Babraham Research Campus, Cambridge, UK. Electronic address: al989@cam.ac.uk.
Jazyk:	angličtina
Zdroj:	Immunity [Immunity] 2024 Jul 09; Vol. 57 (7), pp. 1586-1602.e10. Date of Electronic Publication: 2024 Jun 18.
DOI:	10.1016/j.immuni.2024.05.023
Abstrakt:	The tissues are the site of many important immunological reactions, yet how the immune system is controlled at these sites remains opaque. Recent studies have identified Foxp3 + regulatory T (Treg) cells in non-lymphoid tissues with unique characteristics compared with lymphoid Treg cells. However, tissue Treg cells have not been considered holistically across tissues. Here, we performed a systematic analysis of the Treg cell population residing in non-lymphoid organs throughout the body, revealing shared phenotypes, transient residency, and common molecular dependencies. Tissue Treg cells from different non-lymphoid organs shared T cell receptor (TCR) sequences, with functional capacity to drive multi-tissue Treg cell entry and were tissue-agnostic on tissue homing. Together, these results demonstrate that the tissue-resident Treg cell pool in most non-lymphoid organs, other than the gut, is largely constituted by broadly self-reactive Treg cells, characterized by transient multi-tissue migration. This work suggests common regulatory mechanisms may allow pan-tissue Treg cells to safeguard homeostasis across the body. Competing Interests: Declaration of interests A.L. and J.D. are founders of Aila Biotech Ltd. A.L. has served on advisory boards for Imcyse, Sangamo, Dualyx, and Enhanc3D. C.P.R. is currently employed at CSL Behring. S.T. is currently employed at Roche. S.J. and A.B. are currently employed at Janssen Pharmaceuticals. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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