Lippia alba essential oil: A powerful and valuable antinociceptive and anti-inflammatory medicinal plant from Brazil.

Autor: Froz MJDL; Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66095-015, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém, 66075-110, Brazil. Electronic address: biomedicajulianafz@gmail.com., Barros LSP; Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66095-015, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém, 66075-110, Brazil. Electronic address: luana.barros@ics.ufpa.br., de Jesus ENS; Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66095-015, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém, 66075-110, Brazil. Electronic address: jesusellen02@gmail.com., Tavares MS; Laboratório de Morfofisiologia Aplicada a Saúde, Universidade do Estado do Pará, Belém, 66087-670, Brazil. Electronic address: mateusilvatav@gmail.com., Mourão RHV; Laboratório de Bioprospecção e Biologia Experimental, Universidade Federal do Oeste do Pará, Santarém, 68035-110, Brazil. Electronic address: rosa.mourao@ufopa.edu.br., Silva RC; Laboratório de Morfofisiologia Aplicada a Saúde, Universidade do Estado do Pará, Belém, 66087-670, Brazil. Electronic address: renatacsterapeuta@gmail.com., de Lima AB; Laboratório de Morfofisiologia Aplicada a Saúde, Universidade do Estado do Pará, Belém, 66087-670, Brazil. Electronic address: andersonbentes@uepa.br., da Silva PIC; Laboratório de Morfofisiologia Aplicada a Saúde, Universidade do Estado do Pará, Belém, 66087-670, Brazil. Electronic address: pedroiuric.silva@gmail.com., Freitas JJS; Laboratório de Morfofisiologia Aplicada a Saúde, Universidade do Estado do Pará, Belém, 66087-670, Brazil. Electronic address: jofre.freitas@uepa.br., Setzer WN; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA. Electronic address: wsetzer@aromaticplant.org., da Silva JKR; Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, Belém, 66075-900, Brazil. Electronic address: joycekellys@ufpa.br., Negrão JNC; Laboratório de Morfofisiologia Aplicada a Saúde, Universidade do Estado do Pará, Belém, 66087-670, Brazil. Electronic address: nazareno.negrao@uepa.br., Figueiredo PLB; Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66095-015, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém, 66075-110, Brazil. Electronic address: pablo.figueiredo@uepa.br.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Oct 28; Vol. 333, pp. 118459. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1016/j.jep.2024.118459
Abstrakt: Ethnopharmacological Relevance: In Brazilian popular medicine, Lippia alba leaves are used in teas to treat pain and inflammatory diseases.
Aim of the Study: to evaluate the chemical composition, antinociceptive, and anti-inflammatory activities of Lippia alba essential oil and its major compound geraniol.
Material and Methods: Lippia alba leaves were collected in Pará state, Brazil. The leaf essential oil was obtained using a modified Clevenger-type extractor. Then, the oil was analyzed by GC and GC-MS analyses. To evaluate the toxicity of LaEO and geraniol, the doses of 50, 300, and 2000 mg/kg were used in a mouse model. For antinociception tests, abdominal contortion, hot plate, and formalin tests were used; all groups were treated with LaEO and geraniol at doses of 25, 50, and 100 mg/kg; and to evaluate inflammation using the ear edema model.
Results: The constituents identified in the highest content were oxygenated monoterpenes: geraniol (37.5%), geranial (6.7%) and neral (3.8%). The animals treated with LaEO and geraniol demonstrated atypical behaviors with aspects of lethargy and drowsiness, characteristics of animals in a state of sedation; the relative weights showed no significant difference compared to the controls. In the abdominal contortion test, LaEO at 25 mg/kg, 50 mg/kg doses, and 100 mg/kg reduced the number of contortions, representing a percentage reduction of 84.64%, 81.23%, and 66.21% respectively. In the hot plate test, LaEO and geraniol increased the latency time at doses of 25, 50, and 100 mg/kg in all test periods; there was no statistical difference between LaEO and geraniol. In the first phase of the formalin test, only doses of 25 mg/kg and 100 mg/kg of LaEO showed significant activity, reducing the latency time by 53.40% and 58.90%. LaEO at doses of 25 mg/kg and 100 mg/kg reduced the size of the edema, demonstrating an anti-inflammatory activity of 59.38% (25 mg/kg) and 50% (100 mg/kg).
Conclusion: Lippia alba essential oil and geraniol showed central/peripheral analgesic and anti-inflammatory potential and can be used as an alternative or complementary treatment to conventional drugs. More studies are needed to evaluate its action mechanisms and its analgesic effects.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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