Impact on pulmonary, cardiac, and renal function and long-term quality of life after hospitalization for acute respiratory distress syndrome due to COVID-19: Protocol of the Post-COVID Brazil 3 study.

Autor:	Scolari FL; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Rover MM; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Trott G; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., da Silva MMD; Research Institute, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., de Souza D; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., de Carli Schardosim RF; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., da Rosa Minho Dos Santos R; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., de Souza Roldão E; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Mocellin D; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., de Souza JMB; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Miozzo AP; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Rech GS; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Itaqui CR; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., de Mesquita Neto J; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Estivalete GPM; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Freitas HJM; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Dos Santos CVP; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., da Luz LG; Department of Nephrology, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Kern M; Department of Internal Medicine, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Marcolino MS; Department of Clinical Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brazil., Barreto BB; Department of Internal Medicine and Diagnostic Support, Faculdade de Medicina da Bahia, Universidade Federal da Bahia - Salvador (BA), Brazil., Schwartzman PR; Departamento de Cardiologia, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Antonio ACP; Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brazil., Falavigna M; Research Unit, Inova Medical - Porto Alegre (RS), Brasil., Robinson CC; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Polanczy CA; Departamento de Cardiologia, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil., Rosa RG; Project Offices, Hospital Moinhos de Vento - Porto Alegre (RS), Brazil.
Jazyk:	English; Portuguese
Zdroj:	Critical care science [Crit Care Sci] 2024 Jun 17; Vol. 36, pp. e20240258en. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2024).
DOI:	10.62675/2965-2774.20240258-en
Abstrakt:	Rationale: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. Purpose: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. Methods: This will be a multicenter case-control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. Results: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. Conclusion: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population.
Databáze:	MEDLINE
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