Association of estimated pulse wave velocity with cognitive function in a multiethnic diverse population: The Northern Manhattan Study.

Autor: Aimagambetova B; Evelyn F. McKnight Brain Institute, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Ariko T; Evelyn F. McKnight Brain Institute, Miami, Florida, USA.; Department of Biomedical Engineering, University of Miami, Miami, Florida, USA., Gardener H; Evelyn F. McKnight Brain Institute, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Levin B; Evelyn F. McKnight Brain Institute, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Sun X; Evelyn F. McKnight Brain Institute, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Gutierrez J; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA., Elkind MS; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA., Wright CB; Stroke Branch, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA., Rundek T; Evelyn F. McKnight Brain Institute, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4903-4913. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1002/alz.14064
Abstrakt: Introduction: Arterial stiffness is linked to age-related cognitive dysfunction. Estimated pulse wave velocity (ePWV) is associated with cerebrovascular disease. We sought to determine whether ePWV was associated with cognition in a multiethnic population.
Methods: We included 1257 participants enrolled in a Northern Manhattan Study magnetic resonance imaging MRI-cognitive study (mean age 64 ± 8 years, 61% women, 67% Hispanic, 18% non-Hispanic Black, 15% non-Hispanic white) and analyzed cognitive performance at two time points, at enrollment and on an average 5.0 ± 0.6 years later. ePWV was calculated using baseline age and blood pressure. Cognition and cognitive change scores were regressed on ePWV in multivariable linear regression models.
Results: In adjusted models, ePWV (mean 11 ± 2 m/s) was significantly associated with cognition (b = -0.100, 95% CI, -0.120, -0.080) and cognitive change over time (b = -0.063, 95% CI, -0.082, -0.045). Effect modification by race and sex was found.
Discussion: In this multiethnic population, the associations of ePWV with cognitive performance underline the role of vascular stiffness in age-related cognitive decline.
Highlights: ePWV is a modest but independent predictor of cognitive function and cognitive decline among older individuals. After adjustment, the ePWV measure was inversely associated with performance and decline in global cognition, processing speed, episodic memory, executive function, and semantic memory. After adjustment, modification of the association between ePWV and change in episodic memory and executive function by race and ethnicity was suggested by a significant interaction term. The association between ePWV and episodic memory decline was stronger in females.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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