The importance of multimodal CT examination in stroke mimics diagnosis: design of prospective observational multicentre study.

Autor:	Dvorníková K; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia., Kunešová V; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia.; Cerebrovascular research program, International Clinical Research Center, Brno, Czechia., Ely M; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia.; Cerebrovascular research program, International Clinical Research Center, Brno, Czechia., Ostrý S; Hospital in České Budejovice A.S., České Budějovice, Czechia., Čábal M; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia., Reiser M; Hospital in České Budejovice A.S., České Budějovice, Czechia., Machová L; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia., Pavlínová M; Hospital in České Budejovice A.S., České Budějovice, Czechia., Kondé A; Department of the Deputy Director for Science, Research and Education, University Hospital in Ostrava, Ostrava, Czechia.; Department of Applied Mathematics, Faculty of Electrical Engineering and Computer Science, VSB - Technical University of Ostrava, Ostrava, Czechia., Eliáš P; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia., Jonszta T; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia., Havelka J; Department of Imaging Methods, Faculty of Medicine, Ostrava of University, Ostrava, Czechia., Volný O; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia., Bar M; Department of Neurology, University Hospital Ostrava, Ostrava, Czechia.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2024 Jun 04; Vol. 15, pp. 1365986. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).
DOI:	10.3389/fneur.2024.1365986
Abstrakt:	Introduction: Non-contrast computed tomography (CT) and CT angiography are the gold standard in neuroimaging diagnostics in the case of suspected stroke. CT perfusion (CTP) may play an important role in the diagnosis of stroke mimics (SM), but currently, it is not a standard part of the stroke diagnostic procedure. The project is a multicentre prospective observational clinical research focused on refining the diagnostics of stroke and stroke mimics (SM) in hospital care. Aim: This study aimed to evaluate the degree of specificity and sensitivity of multimodal CT (NCCT, CTA, and CTP) in the diagnosis of SM versus stroke. Methodology: In this study, we will include 3,000 patients consecutively admitted to the comprehensive stroke centres with a diagnosis of suspected stroke. On the basis of clinical parameters and the results of multimodal CT and magnetic resonance imaging (MRI), the diagnosis of stroke and SM will be established. To clarify the significance of the use of the multimodal CT scan, the analysis will include a comparison of the blinded results for each imaging scan performed by radiologists and AI technology and a comparison of the initial and final diagnosis of the enrolled patients. Based on our results, we will compare the economic indicators and costs that would be saved by not providing inadequate treatment to patients with SM. Conclusion: The expected outcome is to present an optimised diagnostic procedure that results in a faster and more accurate diagnosis, thereby eliminating the risk of inadequate treatment in patients with SM. Clinical Trial Registration: clinicaltrials.gov, NCT06045455. Competing Interests: MB received a speaker fee from Brainomix ltd in 2021. SO, MR, and MP were employed by Hospital in České Budejovice A.S. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Dvorníková, Kunešová, Ely, Ostrý, Čábal, Reiser, Machová, Pavlínová, Kondé, Eliáš, Jonszta, Havelka, Volný and Bar.)
Databáze:	MEDLINE
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