| Autor: |
Shallow MC; Department of Biology, Washington University in Saint Louis., Tian L; Department of Biology, Washington University in Saint Louis., Lin H; Department of Biology, Washington University in Saint Louis., Lefton KB; Department of Biology, Washington University in Saint Louis.; Department of Neuroscience, Washington University in Saint Louis., Chen S; Department of Genetics, Washington University in Saint Louis., Dougherty JD; Department of Genetics, Washington University in Saint Louis., Culver JP; Department of Radiology, Washington University in Saint Louis., Lambo ME; Department of Biology, Washington University in Saint Louis., Hengen KB; Department of Biology, Washington University in Saint Louis. |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 05. Date of Electronic Publication: 2024 Jun 05. |
| DOI: |
10.1101/2024.06.04.597353 |
| Abstrakt: |
The development of motor control over sensory organs is a critical milestone in sensory processing, enabling active exploration and shaping of the sensory environment. However, whether the onset of sensory organ motor control directly influences the development of corresponding sensory cortices remains unknown. Here, we exploit the late onset of whisking behavior in mice to address this question in the somatosensory system. Using ex vivo electrophysiology, we discovered a transient increase in the intrinsic excitability of excitatory neurons in layer IV of the barrel cortex, which processes whisker input, precisely coinciding with the onset of active whisking at postnatal day 14 (P14). This increase in neuronal gain was specific to layer IV, independent of changes in synaptic strength, and required prior sensory experience. Strikingly, the effect was not observed in layer II/III of the barrel cortex or in the visual cortex upon eye opening, suggesting a unique interaction between the development of active sensing and the thalamocortical input layer in the somatosensory system. Predictive modeling indicated that changes in active membrane conductances alone could reliably distinguish P14 neurons in control but not whisker-deprived hemispheres. Our findings demonstrate an experience-dependent, lamina-specific refinement of neuronal excitability tightly linked to the emergence of active whisking. This transient increase in the gain of the thalamic input layer coincides with a critical period for synaptic plasticity in downstream layers, suggesting a role in facilitating cortical maturation and sensory processing. Together, our results provide evidence for a direct interaction between the development of motor control and sensory cortex, offering new insights into the experience-dependent development and refinement of sensory systems. These findings have broad implications for understanding the interplay between motor and sensory development, and how the mechanisms of perception cooperate with behavior. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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