Insula uses overlapping codes for emotion in self and others.

Autor:	Xiao J; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Adkinson JA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Allawala AB; Department of Engineering, Brown University, Providence, RI, 02912., Banks G; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Bartoli E; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Fan X; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Mocchi M; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Pascuzzi B; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Pulapaka S; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Franch MC; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Mathew SJ; Department of Psychiatry, Baylor College of Medicine, Houston, TX, 77030., Mathura RK; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Myers J; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Pirtle V; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Provenza NR; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Shofty B; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Watrous AJ; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Pitkow X; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Goodman WK; Department of Psychiatry, Baylor College of Medicine, Houston, TX, 77030., Pouratian N; Department of Neurosurgery, University of Texas Southwestern, Dallas, TX, 75390., Sheth S; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Bijanki KR; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030., Hayden BY; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 08. Date of Electronic Publication: 2024 Jun 08.
DOI:	10.1101/2024.06.04.596966
Abstrakt:	In daily life, we must recognize others' emotions so we can respond appropriately. This ability may rely, at least in part, on neural responses similar to those associated with our own emotions. We hypothesized that the insula, a cortical region near the junction of the temporal, parietal, and frontal lobes, may play a key role in this process. We recorded local field potential (LFP) activity in human neurosurgical patients performing two tasks, one focused on identifying their own emotional response and one on identifying facial emotional responses in others. We found matching patterns of gamma- and high-gamma band activity for the two tasks in the insula. Three other regions (MTL, ACC, and OFC) clearly encoded both self- and other-emotions, but used orthogonal activity patterns to do so. These results support the hypothesis that the insula plays a particularly important role in mediating between experienced vs. observed emotions. Competing Interests: Declaration of interests SAS has consulting agreements with Boston Scientific, NeuroPace, Abbott, Zimmer Biomet, Varian Medical, and Sensoria Therapeutics and is co-founder of Motif. WKG has received donated devices from Medtronic and has consulting agreements with Biohaven Pharmaceuticals. SJM has served as a consultant or received research support from the following companies: Abbott, Almatica Pharma, Biohaven, BioXcel Therapeutics, Boehringer-Ingelheim, Brii Biosciences, Clexio Biosciences, COMPASS Pathways, Delix Therapeutics, Douglas Pharmaceuticals, Engrail Therapeutics, Freedom Biosciences, Liva Nova, Levo Therapeutics, Merck, Motif, Neumora, Neurocrine, Perception Neurosciences, Praxis Precision Medicines, Relmada Therapeutics, Sage Therapeutics, Seelos Therapeutics, Signant Health, Sunovion, Xenon Pharmaceuticals, Worldwide Clinical Trials, and XW Pharma. NP is a consultant for Abbott Laboratories and Sensoria Therapeutics. KRB has one patent awarded (US 11,241,575) and a second patent pending (US 63/592,453), which are not related to the findings of the current manuscript. The remaining authors declare no competing interests.
Databáze:	MEDLINE
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