Epidemiological and microbiological characteristics of S. aureus pediatric infections in Colombia 2018-2021, a national multicenter study (Staphylored Colombia).

Autor:	Gutierrez-Tobar I; Department of Pediatrics, Clínica Infantil Santa Maria Del Lago, Bogotá, Colombia.; Department of Pediatrics, Clinica Infantil Colsubsidio, Bogotá, Colombia.; Staphylored LATAM, Bogotá, Colombia., Carvajal C; Staphylored LATAM, Bogotá, Colombia.; Universidad Finis Terrae, Santiago, Chile., Vasquez-Hoyos P; Staphylored LATAM, Bogotá, Colombia.; Department of Pediatrics, Fundacion Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.; Universidad Nacional de Colombia, Bogotá, Colombia.; Sociedad de Cirugía de Bogotá Hospital de San Jose, Bogotá, Colombia., Díaz-Díaz A; Staphylored LATAM, Bogotá, Colombia.; Department of Pediatrics, Hospital Pablo Tobon Uribe, Medellín, Colombia.; Department of Pediatrics, Hospital General de Medellín, Medellín, Colombia., Londono Ruiz JP; Department of Pediatrics, Clinica Infantil Colsubsidio, Bogotá, Colombia.; Staphylored LATAM, Bogotá, Colombia., Andrade J; Staphylored LATAM, Bogotá, Colombia.; Department of Pediatrics, Hospital Militar Central, Bogotá, Colombia., Camacho-Cruz J; Staphylored LATAM, Bogotá, Colombia.; Department of Pediatrics, Fundacion Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.; Universidad Nacional de Colombia, Bogotá, Colombia.; Sociedad de Cirugía de Bogotá Hospital de San Jose, Bogotá, Colombia.; Department of Pediatrics, Fundación Universitaria Sanitas, Bogotá, Colombia.; Department of Pediatrics, Clínica Reina Sofia Pediátrica y Mujer, Bogotá, Colombia., Restrepo-Gouzy A; Department of Pediatrics, Hospital Pablo Tobon Uribe, Medellín, Colombia., Trujillo-Honeysberg M; Department of Pediatrics, Hospital Pablo Tobon Uribe, Medellín, Colombia., Mesa-Monsalve JG; Clínica Las Americas, AUNA, Unidad de Enfermedades Infecciosas, Medellín, Colombia., Perez I; Universidad de los Andes, Santiago, Chile., Von Moltke R; Staphylored LATAM, Bogotá, Colombia.; Universidad Finis Terrae, Santiago, Chile., Beltran-Echeverry M; Department of Pediatrics, Clínica Infantil Santa Maria Del Lago, Bogotá, Colombia.; Staphylored LATAM, Bogotá, Colombia.; Sociedad de Cirugía de Bogotá Hospital de San Jose, Bogotá, Colombia., Toro JF; Department of Pediatrics, Clínica Medilaser, Neiva, Colombia., Niño AP; Department of Pediatrics, Clínica Medilaser, Neiva, Colombia., Camacho-Moreno G; Department of Pediatrics, Fundación Hospital de La Misericordia, Bogotá, Colombia.; Department of Pediatrics, Hospital Universitario Infantil de San José, Bogotá, Colombia., Calle-Giraldo JP; Department of Pediatrics, Hospital San Juan de Dios, Armenia, Colombia.; Department of Pediatrics, Clinica Farallones, Cali, Colombia.; Department of Pediatrics, Clinica Versalles, Cali, Colombia., Cabeza NY; Department of Pediatrics, Hospital San Juan de Dios, Armenia, Colombia., Sandoval-Calle LM; Department of Pediatrics, Fundación Valle de Lili, Cali, Colombia., Perez Camacho P; Department of Pediatrics, Fundación Valle de Lili, Cali, Colombia., Patiño Niño J; Department of Pediatrics, Fundación Valle de Lili, Cali, Colombia., Araque-Muñoz P; Department of Pediatrics, Clinica Country, Bogotá, Colombia.; Department of Pediatrics, Clinica La Colina, Bogotá, Colombia., Rodríguez-Peña Y; Department of Pediatrics, Clinica Country, Bogotá, Colombia.; Department of Pediatrics, Clinica La Colina, Bogotá, Colombia., Beltran-Arroyave C; Department of Pediatrics, Clinica El Rosario, Medellín, Colombia., Chaucanez-Bastidas Y; Department of Pediatrics, Hospital Infantil Los Ángeles, Pasto, Colombia., Lopez J; Department of Pediatrics, Fundación Hospital de La Misericordia, Bogotá, Colombia., Galvis-Trujillo D; Department of Pediatrics, Fundación Hospital de La Misericordia, Bogotá, Colombia., Beltrán-Higuera S; Clinica Colsanitas, Bogotá, Colombia.; Department of Pediatrics, Clinica infantil Colsanitas, Bogotá, Colombia., Marino AC; Department of Pediatrics, Hospital Militar Central, Bogotá, Colombia., González Leal N; Independent Researcher, Manizales, Colombia., Luengas Monroy MÁ; Department of Pediatrics, Hospital Militar Central, Bogotá, Colombia., Hernandez-Moreno DC; Department of Pediatrics, Hospital Militar Central, Bogotá, Colombia., Vivas Trochez R; Department of Pediatrics, Clínica Soma, Medellín, Colombia.; Department of Pediatrics, Hospital Universitario de San Vicente Fundación, Medellín, Colombia., Garces C; Department of Pediatrics, Clinica Cardiovid Medellín, Medellin, Colombia., López-Medina E; Centro de Estudios en Infectología Pediátrica, Cali, Colombia.; Universidad del Valle, Cali, Colombia.; Department of Pediatrics, Clínica Imbanaco, Cali, Colombia.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2024 Jun 04; Vol. 12, pp. 1386310. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).
DOI:	10.3389/fped.2024.1386310
Abstrakt:	Background: Staphylococcus aureus infections are a significant cause of morbidity and mortality in pediatric populations worldwide. The Staphylo Research Network conducted an extensive study on pediatric patients across Colombia from 2018 to 2021. The aim of this study was to describe the epidemiological and microbiological characteristics of S. aureus in this patient group. Methods: We analyzed S. aureus isolates from WHONET-reporting centers. An "event" was a positive culture isolation in a previously negative individual after 2 weeks. We studied center characteristics, age distribution, infection type, and antibiotic susceptibilities, comparing methicillin sensitive (MSSA) and resistant S. aureus (MRSA) isolates. Results: Isolates from 20 centers across 7 Colombian cities were included. Most centers (80%) served both adults and children, with 55% offering oncology services and 85% having a PICU. We registered 8,157 S. aureus culture isolations from 5,384 events (3,345 MSSA and 1,961 MRSA) in 4,821 patients, with a median age of 5 years. Blood (26.2%) and skin/soft tissue (18.6%) were the most common infection sources. Most isolates per event remained susceptible to oxacillin (63.2%), clindamycin (94.3%), and TMP-SMX (98.3%). MRSA prevalence varied by city (<0.001), with slightly higher rates observed in exclusively pediatric hospitals. In contrast, the MRSA rate was somewhat lower in centers with Antimicrobial Stewardship Program (ASP). MRSA was predominantly isolated from osteoarticular infections and multiple foci, while MSSA was more frequently associated with recurrent infections compared to MRSA. Conclusions: This is the largest study of pediatric S. aureus infections in Colombia. We found MSSA predominance, but resistance have important regional variations. S. aureus remains susceptible to other commonly used antibiotics such as TMP-SMX and clindamycin. Ongoing monitoring of S. aureus infections is vital for understanding their behavior in children. Prospective studies within the Staphylored LATAM are underway for a more comprehensive clinical and genetic characterization. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Gutierrez-Tobar, Carvajal, Vasquez-Hoyos, Díaz-Díaz, Londono Ruiz, Andrade, Camacho-Cruz, Restrepo-Gouzy, Trujillo-Honeysberg, Mesa-Monsalve, Perez, Von Moltke, Beltran-Echeverry, Toro, Niño, Camacho-Moreno, Calle-Giraldo, Cabeza, Sandoval-Calle, Perez Camacho, Patiño Niño, Araque-Muñoz, Rodríguez-Peña, Beltran-Arroyave, Chaucanez-Bastidas, Lopez, Galvis-Trujillo, Beltrán-Higuera, Marino, González Leal, Luengas Monroy, Hernandez-Moreno, Vivas Trochez, Garces and López-Medina.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu