Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies.

Autor:	Merola GP; Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy., Tarchi L; Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy., Saccaro LF; Psychiatry Department, Geneva University Hospital and Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland., Delavari F; Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland., Piguet C; Psychiatry Department, Geneva University Hospital and Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland.; General Pediatric Division, Geneva University Hospital, Geneva, Switzerland., Van De Ville D; Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland., Castellini G; Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy., Ricca V; Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2024 Jun 04; Vol. 15, pp. 1378439. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).
DOI:	10.3389/fpsyt.2024.1378439
Abstrakt:	Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, and bipolar disorder. A pathophysiological understanding of intrinsic brain activity underlying psychosis is crucial to improve diagnosis and treatment. While a potential continuum along the psychotic spectrum has been recently described in neuroimaging studies, especially for what concerns absolute and relative amplitude of low-frequency fluctuations (ALFF and fALFF), these efforts have given heterogeneous results. A transdiagnostic meta-analysis of ALFF/fALFF in patients with psychosis compared to healthy controls is currently lacking. Therefore, in this pre-registered systematic review and meta-analysis PubMed, Scopus, and Embase were searched for articles comparing ALFF/fALFF between psychotic patients and healthy controls. A quantitative synthesis of differences in (f)ALFF between patients along the psychotic spectrum and healthy controls was performed with Seed-based d Mapping, adjusting for age, sex, duration of illness, clinical severity. All results were corrected for multiple comparisons by Family-Wise Error rates. While lower ALFF and fALFF were detected in patients with psychosis in comparison to controls, no specific finding survived correction for multiple comparisons. Lack of this correction might explain the discordant findings highlighted in previous literature. Other potential explanations include methodological issues, such as the lack of standardization in pre-processing or analytical procedures among studies. Future research on ALFF/fALFF differences for patients with psychosis should prioritize the replicability of individual studies. Systematic Review Registration: https://osf.io/, identifier (ycqpz). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Merola, Tarchi, Saccaro, Delavari, Piguet, Van De Ville, Castellini and Ricca.)
Databáze:	MEDLINE
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