Factors Associated with Primary Liver Cancer Survival in a Southern Italian Setting in a Changing Epidemiological Scenario.

Autor: Mazzola S; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy., Vittorietti M; Delft University of Technology, 2628 Delft, The Netherlands., Fruscione S; PROMISE Department, University of Palermo, 90127 Palermo, Italy., De Bella DD; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Savatteri A; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Belluzzo M; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Ginevra D; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Gioia A; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Costanza D; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Castellone MD; Istituto di Endocrinologia ed Oncologia Sperimentale del CNR (IEOS), 80100 Napoli, Italy., Costantino C; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy.; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Zarcone M; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy., Ravazzolo B; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy., Graziano G; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy., Mannino R; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy., Amodio R; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy., Di Marco V; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Vitale F; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy.; PROMISE Department, University of Palermo, 90127 Palermo, Italy., Mazzucco W; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy.; PROMISE Department, University of Palermo, 90127 Palermo, Italy.; College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 May 28; Vol. 16 (11). Date of Electronic Publication: 2024 May 28.
DOI: 10.3390/cancers16112046
Abstrakt: A retrospective observational study utilising cancer incidence data from a population-based registry investigated determinants affecting primary liver cancer survival in a southern Italian region with high hepatitis viral infection rates and obesity prevalence. Among 2687 patients diagnosed between 2006 and 2019 (65.3% male), a flexible hazard-based regression model revealed factors influencing 5-year survival rates. High deprivation levels [HR = 1.41 (95%CI = 1.15-1.76); p < 0.001], poor access to care [HR = 1.99 (95%IC = 1.70-2.35); p < 0.0001], age between 65 and 75 [HR = 1.48 (95%IC = 1.09-2.01); p < 0.05] or >75 [HR = 2.21 (95%CI = 1.62-3.01); p < 0.0001] and residing in non-urban areas [HR = 1.35 (95%CI = 1.08-1.69); p < 0.01] were associated with poorer survival estimates. While deprivation appeared to be a risk factor for primary liver cancer patients residing within the urban area, the geographic distance from specialised treatment centres emerged as a potential determinant of lower survival estimates for residents in the non-urban areas. After balancing the groups of easy and poor access to care using a propensity score approach, poor access to care and a lower socioeconomic status resulted in potentially having a negative impact on primary liver cancer survival, particularly among urban residents. We emphasise the need to interoperate cancer registries with other data sources and to deploy innovative digital solutions to improve cancer prevention.
Databáze: MEDLINE
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