| Autor: |
Wowra B; Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.; Department of Ophthalmology, District Railway Hospital, 65 Panewnicka Street, 40-760 Katowice, Poland., Wysocka-Kosmulska M; Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.; Department of Ophthalmology, St. Barbara Hospital, 41-200 Sosnowiec, Poland., Dobrowolski D; Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.; Department of Ophthalmology, District Railway Hospital, 65 Panewnicka Street, 40-760 Katowice, Poland.; Department of Ophthalmology, St. Barbara Hospital, 41-200 Sosnowiec, Poland., Wylęgała E; Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland.; Department of Ophthalmology, District Railway Hospital, 65 Panewnicka Street, 40-760 Katowice, Poland. |
| Abstrakt: |
Background/Objectives : Aniridia-associated keratopathy (AAK) is a potentially vision-threatening pathology in congenital aniridia, for which both the underlying etiopathogenesis and effective treatment remain unclear. Methods :This prospective study was conducted to assess and compare the short-term outcome after superficial keratectomy (SK) alone or in a combination with an amniotic membrane transplantation (AMT). Here, 76 eyes were enrolled in 76 patients with grade 4 AAK. In all eyes, in order to assess preoperatively the efficiency of the limbal epithelial stem cells (LESC), the presence of corneal epithelial cells in confocal microscopy was established. The analyses included: best corrected visual acuity (BCVA), the stage of AAK and the number of corneal quadrants involved in corneal neovascularization (CNV). Results : Six months after surgery, the mean BCVA was 0.05 and ranged from 0.002 up to 0.1 in both groups. Improvement in BCVA occurred in 94.29% patients when *SK alone* was performed, and in 92.68% when in combination with AMT. There were no statistically significant differences in the effect of therapy depending on the type of surgery, regarding BCVA, stage of AAK and the number of quadrants with CNV. Conclusions : SK alone is an effective procedure in short outcomes limited to six months for advanced AAK in association with LESC partial efficiency. |
