The Mediterranean Diet in Pregnancy: Implications for Maternal Brain Morphometry in a Secondary Analysis of the IMPACT BCN Randomized Clinical Trial.

Autor:	Nakaki A; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Gomez Y; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain., Castro-Barquero S; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Department of Internal Medicine Hospital Clinic, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentaria (INSA-UB), University of Barcelona, 08028 Barcelona, Spain., Conti A; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', 00133 Rome, Italy., Vellvé K; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain., Casas I; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Genero M; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain., Youssef L; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Josep Carreras Leukaemia Research Institute, Hospital Clinic/University of Barcelona Campus, 08036 Barcelona, Spain., Segalés L; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain., Benitez L; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Casas R; Department of Internal Medicine Hospital Clinic, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentaria (INSA-UB), University of Barcelona, 08028 Barcelona, Spain., Vieta E; Department of Psychiatry and Psychology, Hospital Clinic, Neuroscience Institute, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Bargallo N; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Radiology Department, Center of Image Diagnostic, Hospital Clínic, Facultad de Medicina, Universidad de Barcelona, 08036 Barcelona, Spain., Toschi N; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', 00133 Rome, Italy.; Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02115, USA., Estruch R; Department of Internal Medicine Hospital Clinic, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentaria (INSA-UB), University of Barcelona, 08028 Barcelona, Spain., Crispi F; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain and Centre for Biomedical Research on Rare Diseases (CIBERER), 08036 Barcelona, Spain., Gratacos E; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain and Centre for Biomedical Research on Rare Diseases (CIBERER), 08036 Barcelona, Spain., Crovetto F; BCNatal|Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, 08028 Barcelona, Spain.; Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain.; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin, RD21/0012/0003, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 May 24; Vol. 16 (11). Date of Electronic Publication: 2024 May 24.
DOI:	10.3390/nu16111604
Abstrakt:	Introduction: A Mediterranean diet has positive effects on the brain in mid-older adults; however, there is scarce information on pregnant individuals. We aimed to evaluate the effect of a structured Mediterranean diet intervention on the cortical structure of the maternal brain during pregnancy. Methods: This study was a secondary analysis of the IMPACT BCN, a randomized clinical trial with 1221 high-risk pregnant women randomly allocated into three groups at 19-23 weeks of gestation: Mediterranean diet intervention, a mindfulness-based stress reduction program, or usual care. Maternal brain magnetic resonance imaging was performed during the third trimester of pregnancy in a random subgroup of participants. For this study, data from the Mediterranean diet and usual groups were analyzed. Maternal dietary intake, adherence to the Mediterranean diet and metabolite biomarkers were evaluated using a food frequency questionnaire, a 17-item dietary screener and plasma/urine samples, respectively. Results: The cluster-wise analysis showed that the Mediterranean diet group participants ( n = 34) had significantly larger surface areas in the right precuneus (90%CI: <0.0001-0.0004, p < 0.001) and left superior parietal (90%CI: 0.026-0.033, p = 0.03) lobules compared to the usual care group participants ( n = 37). A larger right precuneus area was associated with high improvements in adherence to the Mediterranean diet, a high intake of walnuts and high concentrations of urinary hydroxytyrosol. A larger left superior parietal area was associated with a high intake of walnuts and high concentrations of urinary hydroxytyrosol. Conclusions: The promotion of a Mediterranean diet during pregnancy has a significant effect on maternal brain structure.
Databáze:	MEDLINE
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