| Autor: |
Ruocco MR; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy., Gisonna A; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy., Acampora V; Department of Public Health, University of Naples Federico II, 80131 Naples, Italy., D'Agostino A; IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy., Carrese B; IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy., Santoro J; IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy., Venuta A; Department of Public Health, University of Naples Federico II, 80131 Naples, Italy., Nasso R; Department of Movement Sciences and Wellness, University of Naples 'Parthenope', 80133 Naples, Italy., Rocco N; Department of Advanced Biomedical Science, University of Naples Federico II, 80131 Naples, Italy., Russo D; Department of Advanced Biomedical Science, University of Naples Federico II, 80131 Naples, Italy., Cavaliere A; Plastic Surgery Unit, University of Naples Federico II, 80131 Naples, Italy., Altobelli GG; Department of Advanced Biomedical Science, University of Naples Federico II, 80131 Naples, Italy., Masone S; Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy., Avagliano A; Department of Public Health, University of Naples Federico II, 80131 Naples, Italy., Arcucci A; Department of Public Health, University of Naples Federico II, 80131 Naples, Italy., Fiume G; Department of Experimental and Clinical Medicine, University of Catanzaro 'Magna Graecia', 88100 Catanzaro, Italy. |
| Abstrakt: |
Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of cancer cells and an ever-changing tumor microenvironment (TME). The TME includes, among other non-cancer cell types, immune cells influencing the immune context of cancer tissues. In particular, the cross talk of immune cells and their interactions with cancer cells dramatically influence BC dissemination, immunoediting, and the outcomes of cancer therapies. Tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) represent prominent immune cell populations of breast TMEs, and they have important roles in cancer immunoescape and dissemination. Therefore, in this article we review the features of TILs, TAMs, and MDSCs in BCs. Moreover, we highlight the mechanisms by which these immune cells remodel the immune TME and lead to breast cancer metastasis. |
