Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin.

Autor: Edler P; Department of Infectious Diseases, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia., Schwab LSU; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia., Aban M; WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Wille M; WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Centre for Pathogen Genomics, University of Melbourne, Melbourne, Victoria, Australia., Spirason N; WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Deng YM; WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Carlock MA; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.; Department of Infectious Diseases, University of Georgia, Athens, GA, USA.; Florida Research and Innovation Centre, Cleveland Clinic, Port Saint Lucie, FL, USA., Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.; Department of Infectious Diseases, University of Georgia, Athens, GA, USA.; Florida Research and Innovation Centre, Cleveland Clinic, Port Saint Lucie, FL, USA.; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Juno JA; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia., Rockman S; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.; Vaccine Product Development, CSL Seqirus Ltd, Parkville, Victoria, Australia., Wheatley AK; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia., Kent SJ; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Barr IG; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Price DJ; Department of Infectious Diseases, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.; Centre for Epidemiology & Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Koutsakos M; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia. marios.koutsakos@unimelb.edu.au.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2024 Aug; Vol. 9 (8), pp. 2073-2083. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1038/s41564-024-01732-8
Abstrakt: Influenza exposures early in life are believed to shape future susceptibility to influenza infections by imprinting immunological biases that affect cross-reactivity to future influenza viruses. However, direct serological evidence linked to susceptibility is limited. Here we analysed haemagglutination-inhibition titres in 1,451 cross-sectional samples collected between 1992 and 2020, from individuals born between 1917 and 2008, against influenza B virus (IBV) isolates from 1940 to 2021. We included testing of 'future' isolates that circulated after sample collection. We show that immunological biases are conferred by early life IBV infection and result in lineage-specific cross-reactivity of a birth cohort towards future IBV isolates. This translates into differential estimates of susceptibility between birth cohorts towards the B/Yamagata and B/Victoria lineages, predicting lineage-specific birth-cohort distributions of observed medically attended IBV infections. Our data suggest that immunological measurements of imprinting could be important in modelling and predicting virus epidemiology.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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