Prognostic relationship between high sensitivity troponin I level, hematoma volume and glasgow coma score in patients diagnosed with spontaneous intracerebral hemorrhage.

Autor: Ulger H; Department of Emergency Medicine, Health Science University, Adana City Research and Training Hospital, Adana, Turkey., Icme F; Department of Emergency Medicine, Ankara Bilkent City Hospital, Ankara, Turkey. ferhaticme@gmail.com., Parlatan C; Department of Radiology, Health Science University, Adana City Research and Training Hospital, Adana, Turkey., Avci BS; Department of Internal Medicine, Health Science University, Adana City Research and Training Hospital, Adana, Turkey., Aksay E; Department of Emergency Medicine, Health Science University, Adana City Research and Training Hospital, Adana, Turkey., Avci A; Department of Emergency Medicine, Health Science University, Adana City Research and Training Hospital, Adana, Turkey.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2024 Oct; Vol. 193 (5), pp. 2559-2565. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1007/s11845-024-03737-y
Abstrakt: Background: Intracranial hemorrhages is one of the major causes of mortality and morbidity worldwide, and there is still no effective biomarker to predict prognosis.
Aim: We aimed to determine the effectiveness of high sensitive troponin I (hs-cTn-I) levels to predict the prognosis of spontaneous intracerebral hemorrhage (sICH) by comparing Glasgow Coma Score (GCS) and hematoma volume with hs-cTn-I levels.
Methods: This study was planned as a retrospective observational study. Patients with available data, over 18 years old and sICH were included in the study. Cerebral computed tomography images were evaluated by a senior radiologist. Hematoma volume was calculated using the ABC/2 formula.
Results: The study comprised 206 individuals in total 78 (37.86%) women and 128 (62.13%) men. Forty-four (21.35%) of patients died. The sensitivity of GCS, hs-cTn-I, and hematoma volume values were 86.36%, 66.67%, and 59.46%, respectively, with corresponding specificities of 78.75%, 93.02%, and 87.58%. Patients with hs-cTn-I values over 26, GCS values of ≤ 9, and hematoma volume values above 44.16 were found to have higher risk of mortality (p = 0.011; p < 0.001; p < 0.001, respectively). The mortality rates were found to be increased 2.586 (IQR: 1.224-5.463) times in patients with hs-cTn-I values above 26, 0.045 times (IQR: 0.018-0.115) in patients with GCS values ≤ 9, and 7.526 times (IQR: 3.518-16.100) in patients with hematoma volume values above 44.16.
Conclusions: Our findings suggest that hs-cTn-I values exceeding 26 units may serve as effective biochemical markers for predicting the prognosis of patients with sICH.
(© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
Databáze: MEDLINE
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