Long-term voluntary running improves cognitive ability in developing mice by modulating the cholinergic system, antioxidant ability, and BDNF/PI3K/Akt/CREB pathway.

Autor: Wan C; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China; Jiangxi Province Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, China., Shi L; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China., Lai Y; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China., Wu Z; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China., Zou M; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China., Liu Z; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China. Electronic address: lzb19880205@163.com., Meng W; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China; Jiangxi Province Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, China. Electronic address: meng7883@163.com., Wang S; School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, China; Jiangxi Province Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, China. Electronic address: wangsonghua18@126.com.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2024 Jul 27; Vol. 836, pp. 137872. Date of Electronic Publication: 2024 Jun 16.
DOI: 10.1016/j.neulet.2024.137872
Abstrakt: Moderate physical exercise has positive effects on memory. The present study aimed to investigate the impact of long-term exercise on spatial memory in developing mice, as well as its association with the cholinergic system, antioxidant activities, apoptosis factor, and BDNF/PI3K/Akt/CREB pathway in the brain. In this study, Y maze and Novel object recognition (NOR) tests were employed to assess the impact of long-term voluntary exercise on memory. The cholinergic system, antioxidant activities, and apoptosis factors in the brain were quantified using Elisa. Additionally, western blot analysis was conducted to determine the expression of relevant proteins in the BDNF/PI3K/Akt/CREB pathway. The findings demonstrated that prolonged voluntary wheel running exercise enhanced memory in developing mice, concomitant with increased catalase (CAT) activity and decreased malondialdehyde (MDA) levels in the brain. Moreover, it could also increase the hippocampal acetylcholine (ACh) content and suppress the expression of neuronal apoptosis protein. Additionally, exercise also upregulated the expression of brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), phosphoinositide 3 kinases (PI3K), Akt, cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB) in the hippocampus. These findings suggest that long-term voluntary wheel running exercise improves the spatial memory of developing mice by modulating the cholinergic system, antioxidant activities, apoptosis factors, and activating the BDNF/PI3K/Akt/CREB pathway.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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