Seroprevalence of Leptospira antibodies in dogs and cats from Santa Fe, a city in East-Central Argentina endemic for leptospirosis.

Autor: Ricardo T; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina; Dpto. de Ciencias Naturales, Facultad de Humanidades y Ciencias (FHUC), Universidad Nacional del Litoral (UNL), Santa Fe, Argentina. Electronic address: tamararicardo83@gmail.com., Bazán Domínguez LR; Dpto. de Ciencias Naturales, Facultad de Humanidades y Ciencias (FHUC), Universidad Nacional del Litoral (UNL), Santa Fe, Argentina., Beltramini L; Instituto Municipal de Salud Animal (IMuSA), Gobierno de la Ciudad de Santa Fe, Santa Fe, Argentina., Prieto Y; Instituto Municipal de Salud Animal (IMuSA), Gobierno de la Ciudad de Santa Fe, Santa Fe, Argentina; Centro de Investigación sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas (FBCB), Universidad Nacional del Litoral (UNL), Santa Fe, Argentina., Montiel A; Instituto Municipal de Salud Animal (IMuSA), Gobierno de la Ciudad de Santa Fe, Santa Fe, Argentina., Margenet L; Instituto Nacional de Enfermedades Respiratorias (INER) 'Dr. E. Coni', ANLIS 'Dr. C.G. Malbrán', Santa Fe, Argentina., Schmeling MF; Instituto Nacional de Enfermedades Respiratorias (INER) 'Dr. E. Coni', ANLIS 'Dr. C.G. Malbrán', Santa Fe, Argentina., Chiani YT; Instituto Nacional de Enfermedades Respiratorias (INER) 'Dr. E. Coni', ANLIS 'Dr. C.G. Malbrán', Santa Fe, Argentina., Signorini ML; Instituto de Investigación de la Cadena Láctea (INTA - CONICET), Rafaela, Santa Fe, Argentina., Previtali MA; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina; Dpto. de Ciencias Naturales, Facultad de Humanidades y Ciencias (FHUC), Universidad Nacional del Litoral (UNL), Santa Fe, Argentina. Electronic address: andrea.previtali@gmail.com.
Jazyk: angličtina
Zdroj: Preventive veterinary medicine [Prev Vet Med] 2024 Aug; Vol. 229, pp. 106239. Date of Electronic Publication: 2024 May 29.
DOI: 10.1016/j.prevetmed.2024.106239
Abstrakt: This study examines household pets as potential epidemiological links between environments contaminated with pathogenic leptospires and humans in Santa Fe, Argentina. The aims of our study were: (a) to characterize the habits and exposure to environmental sources of leptospirosis in the population of dogs and cats attending to municipal spay and neutering campaigns in Santa Fe, Argentina, (b) to assess the seroprevalence of anti-Leptospira antibodies in asymptomatic dogs and cats, (c) to evaluate factors that could increase seropositivity, and (d) to identify spatial clusters of seropositive dogs and cats in the capital city of Santa Fe. From May to November 2022, a cross-sectional serosurvey was conducted during municipal spaying/neutering campaigns. Eligible household dogs and cats were over 6 months old, apparently healthy, and not vaccinated against leptospirosis in the past 6 months. We used microagglutination test (MAT) to assess anti-Leptospira antibodies using a panel of 10 reference strains. We used generalized linear mixed effects models (GLMM) to examine individual and census tract-level risk factors for seropositivity, and local Moran's I statistic for spatial clusters. Results showed higher leptospiral antibody prevalence in dogs (18.2 %) than cats (3.6 %, p = 0.002). Dogs with street access had higher likelihood of being seropositive (OR: 3.8, 95 % CI: 1.2; 11.9), and areas with chronic poverty showed an elevated risk of presenting seropositive animals (RR: 4.0, 95 % CI: 1.1; 14.4). Spatial analysis didn't reveal significant seropositivity clusters among census tracts. These findings shed light on widespread Leptospira seropositivity in pets in this endemic region. Understanding seroprevalence and risk factors can guide public and veterinary health strategies, emphasizing increased leptospirosis vaccination for dogs in vulnerable areas and promoting responsible pet care.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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