Default mode network electrophysiological dynamics and causal role in creative thinking.

Autor:	Bartoli E; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Devara E; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Dang HQ; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Rabinovich R; Department of Neurosurgery, Clinical Neuroscience Center, University of Utah, Salt Lake City, UT, 84132, USA., Mathura RK; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Anand A; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Pascuzzi BR; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Adkinson J; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA., Kenett YN; Faculty of Data and Decision Sciences, Technion - Israel Institute of Technology, Israel., Bijanki KR; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA., Sheth SA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA., Shofty B; Department of Neurosurgery, Clinical Neuroscience Center, University of Utah, Salt Lake City, UT, 84132, USA.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2024 Jun 18. Date of Electronic Publication: 2024 Jun 18.
DOI:	10.1093/brain/awae199
Abstrakt:	The default mode network (DMN) is a widely distributed, intrinsic brain network thought to play a crucial role in internally-directed cognition. The present study employs stereo-electroencephalography in 13 human patients, obtaining high resolution neural recordings across multiple canonical DMN regions during two processes that have been associated with creative thinking: spontaneous and divergent thought. We probe these two DMN-associated higher cognitive functions through mind wandering and alternate uses tasks, respectively. Our results reveal DMN recruitment during both tasks, as well as a task-specific dissociation in spatiotemporal response dynamics. When compared to the fronto-parietal network, DMN activity was characterized by a stronger increase in gamma band power (30-70 Hz) coupled with lower theta band power (4-8 Hz). The difference in activity between the two networks was especially strong during the mind wandering task. Within the DMN, we found that the tasks showed different dynamics, with the alternate uses task engaging the DMN more during the initial stage of the task, and mind wandering in the later stage. Gamma power changes were mainly driven by lateral DMN sites, while theta power displayed task-specific effects. During alternate uses task, theta changes did not show spatial differences within the DMN, while mind wandering was associated to an early lateral and late dorsomedial DMN engagement. Furthermore, causal manipulations of DMN regions using direct cortical stimulation preferentially decreased the originality of responses in the alternative uses task, without affecting fluency or mind wandering. Our results suggest that DMN activity is flexibly modulated as a function of specific cognitive processes and supports its causal role in divergent thinking. These findings shed light on the neural constructs supporting different forms of cognition and provide causal evidence for the role of DMN in the generation of original connections among concepts. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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