Four dimensions of naturalistic language production in aphasia after stroke.

Autor:	Casilio M; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Kasdan AV; Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Bryan K; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Shibata K; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Schneck SM; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Levy DF; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Entrup JL; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Onuscheck C; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., de Riesthal M; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Wilson SM; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; School of Health and Rehabilitation Sciences, University of Queensland, Brisbane QLD 4072  Australia.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2024 Jun 18. Date of Electronic Publication: 2024 Jun 18.
DOI:	10.1093/brain/awae195
Abstrakt:	There is a rich tradition of research on the neuroanatomical correlates of spoken language production in aphasia using constrained tasks (e.g., picture naming), which offer controlled insights into the distinct processes that govern speech and language (i.e., lexical-semantic access, morphosyntactic construction, phonological encoding, speech motor programming/execution). Yet these tasks do not necessarily reflect everyday language use. In contrast, naturalistic language production (also referred to as connected speech or discourse) more closely approximates typical processing demands, requiring the dynamic integration of all aspects of speech and language. The brain bases of naturalistic language production remain relatively unknown, however, in part because of the difficulty in deriving features that are salient, quantifiable, and interpretable relative to both speech-language processes and the extant literature. The present cross-sectional observational study seeks to address these challenges by leveraging a validated and comprehensive auditory-perceptual measurement system that yields four explanatory dimensions of performance-Paraphasia (misselection of words and sounds), Logopenia (paucity of words), Agrammatism (grammatical omissions), and Motor speech (impaired speech motor programming/execution). We used this system to characterize naturalistic language production in a large and representative sample of individuals with acute post-stroke aphasia (n = 118). Scores on each of the four dimensions were correlated with lesion metrics, and multivariate associations among the dimensions and brain regions were then explored. Our findings revealed distinct yet overlapping neuroanatomical correlates throughout the left-hemisphere language network. Paraphasia and Logopenia were associated primarily with posterior regions, spanning both dorsal and ventral streams, which are critical for lexical-semantic access and phonological encoding. In contrast, Agrammatism and Motor speech were associated primarily with anterior regions of the dorsal stream that are involved in morphosyntactic construction and speech motor planning/execution respectively. Collectively, we view these results as constituting a brain-behavior model of naturalistic language production in aphasia, aligning with both historical and contemporary accounts of the neurobiology of spoken language production. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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