Pharmacokinetics-Pharmacodynamics Modeling for Evaluating Drug-Drug Interactions in Polypharmacy: Development and Challenges.

Autor: Zhao D; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310000, China.; Henan University of Chinese Medicine, Zhengzhou, China., Huang P; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310000, China., Yu L; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China., He Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310000, China. heyu0923@hotmail.com.
Jazyk: angličtina
Zdroj: Clinical pharmacokinetics [Clin Pharmacokinet] 2024 Jul; Vol. 63 (7), pp. 919-944. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1007/s40262-024-01391-2
Abstrakt: Polypharmacy is commonly employed in clinical settings. The potential risks of drug-drug interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating pharmacokinetics (PK) and pharmacodynamics (PD) models into DDIs research provides a reliable method for evaluating and optimizing drug regimens. With advancements in our comprehension of both individual drug mechanisms and DDIs, conventional models have begun to evolve towards more detailed and precise directions, especially in terms of the simulation and analysis of physiological mechanisms. Selecting appropriate models is crucial for an accurate assessment of DDIs. This review details the theoretical frameworks and quantitative benchmarks of PK and PD modeling in DDI evaluation, highlighting the establishment of PK/PD modeling against a backdrop of complex DDIs and physiological conditions, and further showcases the potential of quantitative systems pharmacology (QSP) in this field. Furthermore, it explores the current advancements and challenges in DDI evaluation based on models, emphasizing the role of emerging in vitro detection systems, high-throughput screening technologies, and advanced computational resources in improving prediction accuracy.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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