Health-related quality of life and problem behaviour after GH cessation in adults born SGA: a 12-year follow-up study.

Autor:	Dorrepaal DJ; Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands., van der Steen M; Department of Pediatrics, Subdivision of Endocrinology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., de Ridder M; Department of Medical Informatics, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands., Goedegebuure WJ; Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands., Hokken-Koelega AC; Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jun 18. Date of Electronic Publication: 2024 Jun 18.
DOI:	10.1210/clinem/dgae425
Abstrakt:	Context: Long-term data regarding HRQoL and problem behaviour in adults born SGA who were treated with GH during childhood are lacking. Objective: To investigate longitudinal changes in HRQoL and problem behaviour in adults born SGA during 12 years after cessation of childhood GH-treatment (SGA-GH), and compare these with 3 control groups at age around 30 years. Participants: 176 SGA-GH adults and 3 untreated age-matched control groups: 50 born SGA with short stature (SGA-S), 77 born SGA with spontaneous catch-up growth to normal height (SGA-CU) and 99 born appropriate-for-gestational-age with normal height (AGA). Main Outcome Measures: HRQoL and problem behavior were assessed using TNO-AZL Adults Quality of Life questionnaire (TAAQoL) and Adolescent Behavior Check List (ABCL) at 6 months, 2, 5 and 12 years after GH-cessation. Data at 12-years after GH-cessation were compared with 3 control groups. Results: During 12 years after GH-cessation, HRQoL remained similar on 9 subscales in SGA-GH adults, but decreased on 3 subscales (gross motor functioning, pain, sleep). Externalizing problem behaviour decreased significantly and internalizing problem behaviour tended to decrease. SGA-GH and SGA-S adults had similar HRQoL and problem behaviour. SGA-GH adults had, compared to AGA adults, similar HRQoL on 7 subscales, lower HRQoL on 5 subscales and more internalizing and externalizing problem behaviour. All SGA adults had lower HRQoL and more internalizing problem behaviour than AGA adults. Adult height associated negatively with externalizing problem behaviour, but the influence was small. Conclusions: During 12 years after GH-cessation, HRQoL remained mostly similar and problem behaviour decreased in SGA-GH adults. SGA-GH and SGA-S adults had similar HRQoL and problem behaviour. All SGA adults had lower HRQoL and more internalizing problem behaviour than AGA adults. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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