Sex Differences in Outcomes of an Intensive Risk Factor Modification Program in Patients With Atrial Fibrillation.

Autor:	Noubiap JJ; Centre for Heart Rhythm Disorders, University of Adelaide, Australia (J.J.N., R.K.P., G.T., A.D.E., P.S., M.E.M.).; Division of Cardiology, Department of Medicine, University of California-San Francisco (J.J.N.)., Pathak RK; Centre for Heart Rhythm Disorders, University of Adelaide, Australia (J.J.N., R.K.P., G.T., A.D.E., P.S., M.E.M.).; Australian National University & Canberra Heart Rhythm, Australia (R.K.P.)., Thomas G; Centre for Heart Rhythm Disorders, University of Adelaide, Australia (J.J.N., R.K.P., G.T., A.D.E., P.S., M.E.M.)., Elliott AD; Centre for Heart Rhythm Disorders, University of Adelaide, Australia (J.J.N., R.K.P., G.T., A.D.E., P.S., M.E.M.)., Sanders P; Centre for Heart Rhythm Disorders, University of Adelaide, Australia (J.J.N., R.K.P., G.T., A.D.E., P.S., M.E.M.).; Department of Cardiology, Royal Adelaide Hospital, Australia (P.S.)., Middeldorp ME; Centre for Heart Rhythm Disorders, University of Adelaide, Australia (J.J.N., R.K.P., G.T., A.D.E., P.S., M.E.M.).; Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.E.M.).
Jazyk:	angličtina
Zdroj:	Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2024 Jul; Vol. 17 (7), pp. e012534. Date of Electronic Publication: 2024 Jun 18.
DOI:	10.1161/CIRCEP.123.012534
Abstrakt:	Background: The outcomes of atrial fibrillation (AF) seem to be variable between males and females. We therefore aimed to determine sex differences in weight loss, cardiorespiratory fitness gain, and recurrence and progression of AF following risk factor management. Methods: Of 1415 consecutive patients referred for electrophysiology management of AF, 825 had a body mass index of ≥27 kg/m 2 ; after exclusions, 355 (males, 234; females, 121) were offered risk factor management and participation in a tailored exercise program. Results: Females were older than males (65.5±10.4 versus 62.5±10.6 years; P =0.013) with a higher body mass index (34.1±5.4 versus 32.6±4.1 kg/m 2 ; P =0.003) and more commonly paroxysmal AF (67.8% versus 48.3%; P <0.001). There was no sex difference in clinic attendance (58.7% versus 60%; P =0.82), weight loss ( P =0.86), fitness gain ( P =0.44), or improvement in AF symptoms ( P =0.35). Weight loss (≥10% compared with <10%) was associated with lower total AF recurrence in males (hazard ratio, 0.41 [95% CI, 0.23-0.73]) and females (hazard ratio, 0.41 [95% CI, 0.20-0.83]). Fitness gain (≥2 metabolic equivalents compared with <2 metabolic equivalents) was associated with lower total AF recurrence in females (hazard ratio, 0.13 [95% CI, 0.05-0.30]) but not in males (hazard ratio, 0.63 [95% CI, 0.38-1.04]; P =0.002). There was a trend toward more reversal from persistent to paroxysmal AF in males compared with females (21.8% versus 14.0%; P =0.079). Conclusions: Males and females with AF demonstrate a similar degree of weight loss and fitness gain through structured risk factor management. However, fitness had a much greater benefit for total arrhythmia recurrence in females compared with males, whereas there was a trend toward more AF reversal in males. Registration: URL: https://anzctr.org.au; Unique identifier: ACTRN12614001123639. Competing Interests: Dr Sanders reports having served on the advisory board of Medtronic, Abbott Medical, Boston Scientific, CathRx, and PaceMate. Dr Sanders reports that the University of Adelaide has received on his behalf research funding, lecture, and consulting fees from Medtronic, Abbott Medical, Boston Scientific, and Microport. Dr Pathak reports having served on the advisory board of Medtronic, Abbott Medical, and Boston Scientific. Dr Pathak reports that Canberra Heart Rhythm Foundation has received on his behalf lecture and consulting fees from Medtronic, Abbott Medical, Boston Scientific, and Biotronik. Dr Pathak reports that Canberra Heart Rhythm Foundation has received on his behalf research funding from Medtronic, Abbott Medical, Boston Scientific, and Biotronik.
Databáze:	MEDLINE
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