Candida auris : A Systematic Review of a Globally Emerging Fungal Pathogen in Africa.

Autor: Osaigbovo II; Department of Medical Microbiology, School of Medicine, College of Medical Sciences, University of Benin, Benin City, Nigeria.; Department of Medical Microbiology, University of Benin Teaching Hospital, Benin City, Nigeria., Ekeng BE; Department of Medical Microbiology and Parasitology, University of Calabar Teaching Hospital, Calabar, Nigeria., Davies AA; Department of Medical Microbiology and Parasitology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria., Ebeigbe E; Department of Medical Microbiology, University of Benin Teaching Hospital, Benin City, Nigeria., Bongomin F; Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.; Manchester Fungal Infection Group, Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Kanyua A; Department of Pathology and Laboratory Medicine, Aga Khan University, Nairobi, Kenya., Revathi G; Department of Pathology and Laboratory Medicine, Aga Khan University, Nairobi, Kenya., Oladele RO; Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2023 Dec 27; Vol. 11 (6), pp. ofad681. Date of Electronic Publication: 2023 Dec 27 (Print Publication: 2024).
DOI: 10.1093/ofid/ofad681
Abstrakt: Candida auris is a World Health Organization critical priority fungal pathogen. We conducted a systematic review to describe its epidemiology in Africa. PubMed and Google scholar databases were searched between January 2009 and September 2023 for clinical studies on C. auris cases and/or isolates from Africa. Reviews were excluded. We included 19 studies, involving at least 2529 cases from 6 African countries with the most, 2372 (93.8%), reported from South Africa. Whole-genome sequencing of 127 isolates identified 100 (78.7%) as clade III. Among 527 isolates, 481 (91.3%) were resistant to fluconazole, 108 (20.5%) to amphotericin B, and 9 (1.7%) to micafungin. Ninety of 211 (42.7%) patients with clinical outcomes died. C. auris is associated with high mortality and antifungal resistance, yet this critical pathogen remains underreported in Africa. Collaborative surveillance, fungal diagnostics, antifungals, and sustainable infection control practices are urgently needed for containment.
Competing Interests: Potential conflicts of interest. All authors: No reported conflicts,
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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