Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review.
| Autor: | Petakh P; Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine.; Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Duve K; Department of Neurology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Oksenych V; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Behzadi P; Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran., Kamyshnyi O; Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in neuroscience [Front Neurosci] 2024 Jun 03; Vol. 18, pp. 1394953. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024). |
| DOI: | 10.3389/fnins.2024.1394953 |
| Abstrakt: | This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting the microbiota-gut-brain axis, this study investigated the bidirectional communication between the gut microbiome and mental health. SCFAs, byproducts of gut microbial fermentation, have been examined for their potential impact on PTSD, with a focus on molecular mechanisms and therapeutic interventions. This review discusses changes in SCFA levels and bacterial profiles in individuals with PTSD, emphasizing the need for further research. Promising outcomes from clinical trials using probiotics and fermented formulations suggest potential avenues for PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, and employing advanced computational methods, with the goal of deepening our understanding of the role of SCFAs in PTSD and exploring microbiota-targeted interventions. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Petakh, Duve, Oksenych, Behzadi and Kamyshnyi.) |
| Databáze: | MEDLINE |
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