Gram-negative bacterial infections in surgical intensive care unit patients following abdominal surgery: high mortality associated with Stenotrophomonas maltophilia infection.

Autor: Lin TL; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Chang PH; Chang Gung University College of Medicine, Taoyuan, Taiwan.; Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Liu YW; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Lai WH; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Chen YJ; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Chen IL; Chang Gung University College of Medicine, Taoyuan, Taiwan.; Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan., Li WF; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Wang CC; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Chang Gung University College of Medicine, Taoyuan, Taiwan., Lee IK; Chang Gung University College of Medicine, Taoyuan, Taiwan. leee@cgmh.org.tw.; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. leee@cgmh.org.tw.
Jazyk: angličtina
Zdroj: Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2024 Jun 18; Vol. 13 (1), pp. 65. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1186/s13756-024-01411-7
Abstrakt: Background: Stenotrophomonas maltophilia, a multidrug-resistant gram-negative bacteria (GNB), is an emerging nosocomial pathogen. This study assessed the clinical outcomes of GNB infections in surgical intensive care unit (SICU) patients post-abdominal surgery, focusing on the differences between S. maltophilia and other GNBs, including Pseudomonas aeruginosa.
Methods: A retrospective study was conducted on SICU patients at Kaohsiung Chang Gung Memorial Hospital from 2010 to 2020, who developed GNB infections following abdominal surgery.
Results: Of 442 patients, 237 had S. maltophilia and 205 had non-S. maltophilia GNB infections (including 81 with P. aeruginosa). The overall mortality rate was 44.5%, and S. maltophilia infection emerged as a significant contributor to the mortality rate in patients with GNB infections. S. maltophilia patients had longer mechanical ventilation and SICU stays, with a 30-day mortality rate of 35.4%, higher than the non-S. maltophilia GNB (22.9%) and P. aeruginosa (21%) groups. In-hospital mortality was also higher in the S. maltophilia group (53.2%) compared to the non-S. maltophilia GNB (34.6%) and P. aeruginosa groups (29.6%). Risk factors for acquiring S. maltophilia included a higher Sequential Organ Failure Assessment score and prior broad-spectrum antibiotics use. Older age, polymicrobial infections, and elevated bilirubin were associated with increased 30-day mortality in S. maltophilia patients.
Conclusion: S. maltophilia infections in post-abdominal surgery patients are linked to higher mortality than non-S. maltophilia GNB and P. aeruginosa infections, emphasizing the need for early diagnosis and treatment to improve outcomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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