Effect of manual OCTA segmentation correction to improve image quality and visibility of choroidal neovascularization in AMD.

Autor: Deussen DN; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Department of Ophthalmology, University Hospital, Ludwig-Maximilians-University, 80336, Munich, Germany., Heinke A; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA. aheinke@health.ucsd.edu.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA. aheinke@health.ucsd.edu., Elsner W; The Department of Cognitive Science, University of California San Diego, San Diego, USA., Galang CMB; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA., Kalaw FGP; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA., Warter A; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA., Bartsch DU; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA., Cheng L; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA., Freeman WR; Jacobs Retina Center, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 18; Vol. 14 (1), pp. 13990. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1038/s41598-024-61551-z
Abstrakt: In this retrospective case series on neovascular age-related macular degeneration (nAMD), we aimed to improve Choroidal Neovascularization (CNV) visualization in Optical Coherence Tomography Angiography (OCTA) scans by addressing segmentation errors. Out of 198 eyes, 73 OCTA scans required manual segmentation correction. We compared uncorrected scans to those with minimal (2 corrections), moderate (10 corrections), and detailed (50 corrections) efforts targeting falsely segmented Bruch's Membrane (BM). Results showed that 55% of corrected OCTAs exhibited improved quality after manual correction. Notably, minimal correction (2 scans) already led to significant improvements, with additional corrections (10 or 50) not further enhancing expert grading. Reduced background noise and improved CNV identification were observed, with the most substantial improvement after two corrections compared to baseline uncorrected images. In conclusion, our approach of correcting segmentation errors effectively enhances image quality in OCTA scans of nAMD. This study demonstrates the efficacy of the method, with 55% of resegmented OCTA images exhibiting enhanced quality, leading to a notable increase in the proportion of high-quality images from 63 to 83%.
(© 2024. The Author(s).)
Databáze: MEDLINE
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