Diet predisposes to pancreatic cancer through cellular nutrient sensing pathways.

Autor: Noè R; Veneto Institute of Molecular Medicine (VIMM), Padua, Italy.; Department of Biology, University of Padova, Padua, Italy., Carrer A; Veneto Institute of Molecular Medicine (VIMM), Padua, Italy.; Department of Biology, University of Padova, Padua, Italy.
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2024 Oct; Vol. 598 (20), pp. 2470-2481. Date of Electronic Publication: 2024 Jun 17.
DOI: 10.1002/1873-3468.14959
Abstrakt: Pancreatic cancer is a lethal disease with limited effective treatments. A deeper understanding of its molecular mechanisms is crucial to reduce incidence and mortality. Epidemiological evidence suggests a link between diet and disease risk, though dietary recommendations for at-risk individuals remain debated. Here, we propose that cell-intrinsic nutrient sensing pathways respond to specific diet-derived cues to facilitate oncogenic transformation of pancreatic epithelial cells. This review explores how diet influences pancreatic cancer predisposition through nutrient sensing and downstream consequences for (pre-)cancer cell biology. We also examine experimental evidence connecting specific food intake to pancreatic cancer progression, highlighting nutrient sensing as a promising target for therapeutic development to mitigate disease risk.
(© 2024 Federation of European Biochemical Societies.)
Databáze: MEDLINE
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