The interplay of oxytocin and sex hormones.

Autor: Quintana DS; Department of Psychology, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway; NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway. Electronic address: daniel.quintana@psykologi.uio.no., Glaser BD; Department of Psychology, University of Oslo, Oslo, Norway., Kang H; Department of Psychology, University of Oslo, Oslo, Norway., Kildal ESM; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Psychiatry, Lovisenberg Diakonale Sykehus, Oslo, Norway., Audunsdottir K; Department of Psychology, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Sartorius AM; Department of Psychology, University of Oslo, Oslo, Norway., Barth C; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2024 Aug; Vol. 163, pp. 105765. Date of Electronic Publication: 2024 Jun 15.
DOI: 10.1016/j.neubiorev.2024.105765
Abstrakt: The neuropeptide oxytocin has historically been associated with reproduction and maternal behavior. However, more recent research has uncovered that oxytocin has a much wider range of roles in physiology and behavior. Despite the excitement surrounding potential therapeutical applications of intranasally administered oxytocin, the results of these intervention studies have been inconsistent. Various reasons for these mixed results have been proposed, which tend to focus on methodological issues, such as study design. While methodological issues are certainly important, emerging evidence suggests that the interaction between oxytocin and sex hormones may also account for these varied findings. To better understand the purpose and function of the interaction of oxytocin with sex hormones, with a focus on estrogens, progesterone, and testosterone, we conducted a comprehensive thematic review via four perspectives: evolutionary, developmental, mechanistic, and survival. Altogether, this synergistic approach highlights the critical function of sex hormone activity for accomplishing the diverse roles of oxytocin via the modulation of oxytocin release and oxytocin receptor activity, which is also likely to contribute to the heterogeneity of outcomes after oxytocin administration.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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