Development and characterization of an emulgel based on a snail slime useful for dermatological applications.

Autor: Pagano C; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy. Electronic address: cinzia.pagano@unipg.it., Ceccarini MR; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy., Marinelli A; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy., Imbriano A; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy., Beccari T; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy., Primavilla S; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Via Salvemini 1, 06126 Perugia, Italy., Valiani A; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Via Salvemini 1, 06126 Perugia, Italy., Ricci M; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy., Perioli L; Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2024 Jul 20; Vol. 660, pp. 124337. Date of Electronic Publication: 2024 Jun 15.
DOI: 10.1016/j.ijpharm.2024.124337
Abstrakt: Snail slime is an interesting material for effective dermatological use (e.g. wounds). Its properties are stricly connected to the origin. In this paper a snail slime, deriving from the species Helix aspersa Muller and obtained from a company, was deeply characterized and then properly formulated. The slime, obtained by Donatella Veroni method, was firstly submitted to NMR analysis in order to evaluate the chemical composition. The main molecules found are glycolate and allantoin, well known for their activities in wound healing promotion. In vitro experiments performed on keratinocytes, revealed the snail slime ability to promote cellular well-being. Moreover, the microbiological analysis showed high activity against many strains involved in wounds infections such as gram+ (e.g. S. aureus, S. pyogenes), gram- (e.g. P. aeruginosa, E. coli) and the yeast C. albicans. The effect on skin elasticity was evaluated as well by the instrument Cutometer® dualMPA580. The snail slime was then formulated as hydrophilic gel, using a combination of corn starch and sodium hyaluronate as polymers, then used as external water phase of an O/W emulgel. The formulation is physically stable and easily spreadable and demonstrated antimicrobial activity as observed for slime alone, suggesting its suitability to be used for wound treatment.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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