Automated quantitative assessment of bone contusions and overlying articular cartilage following anterior cruciate ligament injury.

Autor: Champagne AA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA., Zuleger TM; Emory Sports Performance And Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio, USA., Warren SM; Emory Sports Performance And Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Smith DR; Emory Sports Performance And Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Lamplot JD; Campbell Clinic Orthopaedic Center, Germantown, Tennessee, USA., Xerogeanes JW; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Slutsky-Ganesh AB; Emory Sports Performance And Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA., Jayaram P; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Patel JM; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Myer GD; Emory Sports Performance And Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.; The Micheli Center for Sports Injury Prevention, Waltham, Massachusetts, USA.; Youth Physical Development Center, Cardiff Metropolitan University, Wales, UK.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, Georgia, United States., Diekfuss JA; Emory Sports Performance And Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Nov; Vol. 42 (11), pp. 2495-2506. Date of Electronic Publication: 2024 Jun 17.
DOI: 10.1002/jor.25920
Abstrakt: Quantitative methods to characterize bone contusions and associated cartilage injury remain limited. We combined standardized voxelwise normalization and 3D mapping to automate bone contusion segmentation post-anterior cruciate ligament (ACL) injury and evaluate anomalies in articular cartilage overlying bone contusions. Forty-five patients (54% female, 26.4 ± 11.8 days post-injury) with an ACL tear underwent 3T magnetic resonance imaging of their involved and uninvolved knees. A novel method for voxelwise normalization and 3D anatomical mapping was used to automate segmentation, labeling, and localization of bone contusions in the involved knee. The same mapping system was used to identify the associated articular cartilage overlying bone lesions. Mean regional T1ρ was extracted from articular cartilage regions in both the involved and uninvolved knees for quantitative paired analysis against ipsilateral cartilage within the same compartment outside of the localized bone contusion. At least one bone contusion lesion was detected in the involved knee within the femur and/or tibia following ACL injury in 42 participants. Elevated T1ρ (p = 0.033) signal were documented within the articular cartilage overlying the bone contusions resulting from ACL injury. In contrast, the same cartilaginous regions deprojected onto the uninvolved knees showed no ipsilateral differences (p = 0.795). Automated bone contusion segmentation using standardized voxelwise normalization and 3D mapping deprojection identified altered cartilage overlying bone contusions in the setting of knee ACL injury.
(© 2024 Orthopaedic Research Society.)
Databáze: MEDLINE
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