| Autor: |
Leite Lopes D; Department of Biology, State University of Feira de Santana, Feira de Santana, Brazil., Villarreal CF; Department of Pharmacy, Federal University of Bahia, Salvador, Brazil., França Opretzka LC; Department of Pharmacy, Federal University of Bahia, Salvador, Brazil., Soares MBP; ISI-SAS Department, Gonçalo Moniz Institute, FIOCRUZ, Salvador, Brazil., Silva MSD; Department of Research on Drug and Medicines, Federal University of Paraíba, João Pessoa, Brazil., Filho JMB; Department of Research on Drug and Medicines, Federal University of Paraíba, João Pessoa, Brazil., Juiz PJL; CETENS, Federal University of Recôncavo da Bahia, Feira de Santana, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2024 Jun 17, pp. 1-5. Date of Electronic Publication: 2024 Jun 17. |
| DOI: |
10.1080/14786419.2024.2368268 |
| Abstrakt: |
Skin lesions are considered a public health problem, compromising patients' quality of life. This work aimed to evaluate the effects of fraxetin and monnieriside A on Cultured L929 Fibroblasts through the scratch assay. Supernatants and cells from the fibroblast culture treated with the compounds were used to evaluate essential markers of the tissue repair process (IGF-1, VEGF, IL-8, IL-10, FGF-2, COL1A2, COL4A, PDGF) using ELISA and qRT-PCR. The results showed that fraxetin and MOA were non-cytotoxic and could stimulate cellular migration. Fraxetin induced IGF-1, VEGF, IL-8, and IL-10 expression, while MOA induced FGF2, COL1A2, and IL-10 expression. Altogether, these results set provides evidence that fraxetin and MOA have healing potential for tissue repair, paving the way for in vivo studies and clinical trials to validate the in vitro results. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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