Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan., Pallathadka H; Manipur International University, Imphal, Manipur, India. Pallathadkaharikumar1402@gmail.com., Abed HS; Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Ramadi, Iraq. Hussein.salem@uoa.edu.iq., Menon SV; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India., Sivaprasad GV; Department of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Rizaev J; Department of Public health and Healthcare management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, Uzbekistan., Suri S; Centre of Research Impact and Outcome, Chitkara University, Rajpura, 140417, Punjab, India., Jawad MA; Department of Pharmaceutics/ Al-Nisour University College, Baghdad, Iraq., Husseen B; Medical Laboratory Technique College, The Islamic University, Najaf, Iraq.; Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq.
Jazyk: angličtina
Zdroj: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Sep; Vol. 82 (3), pp. 1735-1750. Date of Electronic Publication: 2024 Jun 17.
DOI: 10.1007/s12013-024-01350-5
Abstrakt: The first host defense systems are the innate immune response and the inflammatory response. Among innate immune cells, macrophages, are crucial because they preserve tissue homeostasis and eradicate infections by phagocytosis, or the ingestion of particles. Macrophages exhibit phenotypic variability contingent on their stimulation state and tissue environment and may be detected in several tissues. Meanwhile, critical inflammatory functions are played by macrophage scavenger receptors, in particular, SR-A1 (CD204) and SR-E3 (CD206), in a variety of pathophysiologic events. Such receptors, which are mainly found on the surface of multiple types of macrophages, have different effects on processes, including atherosclerosis, innate and adaptive immunity, liver and lung diseases, and, more recently, cancer. Although macrophage scavenger receptors have been demonstrated to be active across the disease spectrum, conflicting experimental findings and insufficient signaling pathways have hindered our comprehension of the molecular processes underlying its array of roles. Herein, as SR-A1 and SR-E3 functions are often binary, either protecting the host or impairing the pathophysiology of cancers has been reviewed. We will look into their function in malignancies, with an emphasis on their recently discovered function in macrophages and the possible therapeutic benefits of SR-A1 and SR-E3 targeting.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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