Brain carbon monoxide can suppress the rat micturition reflex through brain γ-aminobutyric acid receptors.

Autor: Yamamoto M; Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan., Shimizu T; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan., Shimizu N; Pelvic Floor Center, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan., Fujieda M; Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan., Saito M; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Jazyk: angličtina
Zdroj: International journal of urology : official journal of the Japanese Urological Association [Int J Urol] 2024 Sep; Vol. 31 (9), pp. 1052-1060. Date of Electronic Publication: 2024 Jun 17.
DOI: 10.1111/iju.15514
Abstrakt: Objectives: To investigate roles of brain carbon monoxide (CO), an endogenous gasotransmitter, in regulation of the rat micturition reflex.
Methods: In urethane-anesthetized (0.8 g/kg, ip) male rats, evaluation of urodynamic parameters was started 1 h before intracerebroventricular administration of CORM-3 (CO donor) or ZnPP (non-selective inhibitor of heme oxygenase, a CO producing enzyme) and continued for 2 h after the administration. We also investigated effects of centrally pretreated SR95531 (GABA A receptor antagonist) or SCH50911 (GABA B receptor antagonist) on the CORM-3-induced response.
Results: CORM-3 significantly prolonged intercontraction intervals (ICIs) without changing maximal voiding pressure (MVP), while ZnPP significantly shortened ICI and reduced single-voided volume and bladder capacity without affecting MVP, post-voided residual volume, or voiding efficiency. The ZnPP-induced ICI shortening was reversed by CORM-3. The CORM-3-induced ICI prolongation was significantly attenuated by centrally pretreated SR95531 or SCH50911, respectively.
Conclusions: Brain CO can suppress the rat micturition reflex through brain γ-aminobutyric acid (GABA) receptors.
(© 2024 The Author(s). International Journal of Urology published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Urological Association.)
Databáze: MEDLINE
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